Comparing two breathing-machine methods in patients with asthma or COPD flare-ups
Compares two ways of mechanical ventilation in adults on breathing machines with asthma or COPD.
Plain-language title generated from the registry record
Registry title: FCV vs VCV in Obstructive and Asthmatic Patients
Key facts
- Where
- Rotterdam, NetherlandsSee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 100 years old?
Source: NCT06563544, who can take part
Where in Netherlands
- Erasmus Medical CenterRotterdam, NetherlandsTaking people
- Maasstad HospitalRotterdam, NetherlandsTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Erasmus Medical Center
- Trial code
- NCT06563544
- Record updated
- 13 August 2026
- Original description
The goal of this physiological pilot study with a randomized crossover design is to study the effect of Flow-controlled ventilation (FCV) on the minute volume compared to Volume-controlled ventilation (VCV) in intubated patients with an exacerbation of their asthma or COPD.Read full original descriptionShow less
Flow Versus Volume-Controlled Ventilation in Intubated Obstructive and Asthmatic Patients
The goal of this physiological pilot study with a randomized crossover design is to study the effect of Flow-controlled ventilation (FCV) on the minute volume compared to Volume-controlled ventilation (VCV) in intubated patients with an exacerbation of their asthma or COPD.
Our hypothesis is that FCV will results in a lower minute volume compared to VCV in this patient category.
Patients will be randomized between two ventilation sequences, namely 90 minutes of FCV followed by 90 minutes of VCV or vice versa.
Inclusion: 18 years or older; Provided written informed consent; Undergoing controlled mechanical ventilation via an endotracheal tube; Reason for intubation being exacerbation of asthma or COPD; Intubated ≤72 hours.
Exclusion: Inability to perform adequate electrical impedance tomography (EIT) measurements with, e.g.:; Have a thorax circumference inappropriate for EIT-belt; Thoracic wounds, bandages or deformities preventing adequate fit of EIT-belt; Recent (<7 days) pulmonary surgery including pneumonectomy, lobectomy or lung transplantation; ICD device present (potential interference with proper functioning of the EIT device and ICD device); Excessive subcutaneous emphysema; Contra-indications for nasogastric tube or inability to perform adequate transpulmonary pressure measurements with, e.g.:; Recent esophageal surgery; Prior esophagectomy; Known presence of esophageal varices; Severe bleeding disorders; Severe sputum stasis or production requiring frequent bronchial suctioning (more than 5 times per nurse shift); Untreated pneumothorax (i.e. no pleural drainage); Hemodynamic instability defined as a mean arterial pressure below 60mmHg not responding to fluids and/or vasopressors or a noradrenalin dose >0.5mcrg/kg/min; High (>15 mmHg) or instable (an increase in sedation or osmotherapy is required) intracranial pressure; An inner tube diameter of 6mm or less; Anticipating withdrawal of life support and/or shift to palliation as the goal of care.