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Studying how growth hormone affects insulin-making cells in women with gestational diabetes

Studies how growth hormone affects insulin-making cells in women with past gestational diabetes.

Key facts

Who runs it
University of Missouri-Columbia
Where
Columbia, United StatesSee the site
Trial code
Registry title
Growth Hormone Resistance of Beta-cells A
Status
Recruiting
People taking part
30 people, planned
Started
22 Oct 2025
Expected to end
1 Sept 2030
Type of study
Observational, 2 groups
Record updated
11 May 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for women aged 18 to 45 who had a single full-term pregnancy in the past 5 years. Some had gestational diabetes and some did not.

Age
18 to 45 years
Sex
Women only
Disease stage
Gestational Diabetes Group: gestational diabetes in the most recent pregnancy. Control Group: no history of gestational diabetes.
Earlier treatment
Cannot use medicines that can affect the study results, such as GLP-1 receptor agonists. No bariatric surgery in the past.

Main reasons for not taking part

  • Currently pregnant, planning pregnancy during the study, or breastfeeding
  • Type 1 or type 2 diabetes now or in the past
  • History of bariatric surgery
  • Current cancer, or cancer in remission less than 5 years
  • First degree relative with diabetes

The registry criteria, word for word

Show all 16 criteriaShow less

Who can take part

  • Singleton, full term pregnancy within the past 5 years
  • Body mass index ≥18.5 kg/m2 and <45.0 kg/m2; Group specific inclusion criteria:
  • Gestational Diabetes Group: History of gestational diabetes in the most recent pregnancy
  • Control Group: no history of gestational diabetes

Who cannot take part

  • Use of medications that can impact the study outcomes (e.g., GLP-1 receptor agonists)
  • Current diagnosis or history of type 1 or type 2 diabetes
  • History of bariatric surgery
  • History of intracranial hypertension, including papilledema, or a condition that increases the risk of developing intracranial hypertension, such as Turner Syndrome, Prader-Willi Syndrome, or renal impairment
  • Current cancer or cancer that has been in remission less than 5 years
  • First degree relative with diabetes diagnosis
  • Evidence of significant anemia or significant end organ dysfunction (e.g., liver, kidney, heart disease)
  • Alcohol use disorder, use of controlled substances, or smoking >2 cigarettes per day
  • Pregnant, planning to become pregnant during the study, or breastfeeding
  • Known, uncontrolled hypothyroidism
  • Greater than 3% weight loss within three months of screening or engaged in regular (≥3 days per week), continuous moderate- or high-intensity exercise of ≥30 min duration
  • Mentally disabled persons, prisoners, and persons with inability to grant voluntary informed consent

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 45 years old?

Where in United States

  • University of Missouri School of MedicineColumbia, United StatesContact: Bettina MittendorferTaking people

About the trial

What the trial wants to find out

The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with a personal history of gestational diabetes (high blood sugar in pregnancy) at the University of Missouri. The aim of the study is to advance understanding of how growth hormone affects beta-cells and risk factors for developing gestational diabetes.

The 2 groups in the trial

  • Women with a history of gestational diabetes mellitus
  • Women without a history of gestational diabetes mellitus

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Growth Hormone Resistance of Beta-cells in Women With Gestational Diabetes Mellitus
Plain-language title
Studying how growth hormone affects insulin-making cells in women with gestational diabetesGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Fit questions
Built from NCT06571487, who can take part
Record updated
11 May 2026