Studying Endometriosis and Adenomyosis to Improve Diagnosis in Women
Observational study collecting samples to improve diagnosis of endometriosis and adenomyosis.
Plain-language title generated from the registry record
Registry title: Next-Generation Endometriosis Diagnostics Through Comprehensive Multi-Dimensional Analysis
Key facts
- Where
- Catanzaro and Milan, ItalySee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 40 years old?
Source: NCT06572852, who can take part
Where in Italy
- Azienda Ospedaliero- Universitaria "Renato Dulbecco" di CatanzaroCatanzaro, ItalyNo longer taking part
- IRCCS San Raffaele HospitalMilan, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- IRCCS San Raffaele
- Trial code
- NCT06572852
- Record updated
- 7 October 2025
- Original description
This study is a multicentric, observational, case-control, non-profit with additional procedures. It aims to deepen the understanding of the chronic gynecological conditions of endometriosis and adenomyosis, which significantly impact women's reproductive health. Its purpose is to improve early diagnosis and personalized treatment of these conditions using a multi-omic approach, that integrates genetic, epigenetic, imaging, and endometrial receptivity data. The goal is also to refine image-based predictions through recent advancements in artificial intelligence and to study uterine extracellular vesicles to assess fertility non-invasively.Read full original descriptionShow less
Next-Generation Endometriosis Diagnostics Through Comprehensive Multi-Dimensional Analysis
This study is a multicentric, observational, case-control, non-profit with additional procedures. It aims to deepen the understanding of the chronic gynecological conditions of endometriosis and adenomyosis, which significantly impact women's reproductive health. Its purpose is to improve early diagnosis and personalized treatment of these conditions using a multi-omic approach, that integrates genetic, epigenetic, imaging, and endometrial receptivity data. The goal is also to refine image-based predictions through recent advancements in artificial intelligence and to study uterine extracellular vesicles to assess fertility non-invasively.
The study targets patients with endometriosis and/or adenomyosis and involves women seeking fertility treatments at assisted reproduction centers, who will serve as a control population.
The study comprises both prospective and retrospective components. The prospective recruitment involves the collection of blood and uterine fluid samples, while the retrospective element utilizes pre-existing biobank samples for comprehensive genetic and epigenetic analysis.
Inclusion: Participants eligible for cases with endometriosis and adenomyosis, must meet the following criteria:; Able to give informed consent for participation in the study; European descent; Confirmed diagnosis of both endometriosis and adenomyosis through ultrasound screening; Listed for assisted reproductive treatment, specifically within their first or second IVF cycle; Participants eligible for cases with only endometriosis must meet the following criteria:; Able to give informed consent for participation in the study; European descent; Confirmed diagnosis of endometriosis with no ultrasound evidence of adenomyosis; Enrolled in an assisted reproductive treatment cycle involving embryo thawing; Participants eligible for cases with only adenomyosis must meet the following criteria:; Able to give informed consent for participation in the study; European descent; Confirmed diagnosis of adenomyosis with no ultrasound evidence of endometriosis; Enrolled in an assisted reproductive treatment cycle involving embryo thawing; Participants eligible as controls must meet the following criteria:; Able to give informed consent for participation in the study; European descent; Undergone ultrasound screenings that have excluded the presence of endometriosis or adenomyosis; Listed for assisted reproductive treatment, specifically within their first or second IVF cycle; Presence of reduced ovarian reserve or non-severe male factor infertility.
Exclusion: Patients unable or unwilling to sign the informed consent; Individuals who exhibit the presence of sactosalpinx or other uterine pathologies such as fibroids, polyps, or irregular endometrial thickening will be excluded from participation in this study; These exclusion criteria are applicable across all groups to ensure the accuracy and reliability of the study's findings related to endometriosis and adenomyosis.