Exercise Therapy on Rheological Functions of Erythrocyte in Hemodialysis
Reason given: The study was not initiated, and no participants were enrolled.
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Trial details
- Who runs it
- Chang Gung Memorial Hospital
- Trial code
- NCT06575634
- Record updated
- 16 September 2026
- Original description
To improve aerobic capacity, muscular function, and health-related quality of life in patients with end-stage renal disease (ESRD), regular exercise is recommended. Supervised intradialytic exercise at moderate intensity is a viable approach to ensure patient safety, maintain compliance, and effectively enhance physiological adaptations. However, the impact of exercise training on erythrocyte rheological properties in ESRD patients, such as red blood cell deformability, aggregation, and oxygen transport capacity, remains unclear.Read full original descriptionShow less
Effects of Supervised Exercise on Rheological Functions of Erythrocyte in Patients With End-Stage Renal Disease on Hemodialysis
To improve aerobic capacity, muscular function, and health-related quality of life in patients with end-stage renal disease (ESRD), regular exercise is recommended. Supervised intradialytic exercise at moderate intensity is a viable approach to ensure patient safety, maintain compliance, and effectively enhance physiological adaptations. However, the impact of exercise training on erythrocyte rheological properties in ESRD patients, such as red blood cell deformability, aggregation, and oxygen transport capacity, remains unclear.
Method: ESRD patients (anticipated n=180) will undergo supervised exercise training therapy three times per week for six months in the hospital, followed by three months at home. Cardiopulmonary exercise tests will be conducted before and after the intervention. Erythrocyte deformability and aggregation will be assessed using a laser-assisted optical rotational cell analyzer (LORCA), while additional protein levels and reactive oxygen species (ROS) status will be measured using a flow cytometer. This will help determine how exercise affects the rheological properties of red blood cells in this population.
Inclusion: Receiving hemodialysis and medication at least for 6 weeks; Kt/V score > 1.2.
Exclusion: Having orthopedic or muscular diseases; Other concerned medical, psychological or physiological diseases; Under 20 years-old; Hyperkalemia occurs within 3 month; Pregnancy; Other exercise contraindications.