Tests creatine supplement for recovery after ischemic stroke
Tests creatine against placebo in adults recovering from ischemic stroke.
Plain-language title generated from the registry record
Registry title: Effect of Supplementation With Creatine on the Recovery of Ischemic Stroke
Key facts
- Where
- Palma de Mallorca, SpainSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT06576466, who can take part
Where in Spain
- IdISBaPalma de Mallorca, SpainTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Fundació d'investigació Sanitària de les Illes Balears
- Trial code
- NCT06576466
- Record updated
- 8 July 2025
- Original description
Stroke is a leading cause of disability and the second leading cause of death worldwide. Most strokes are ischemic, caused by acute arterial occlusion. Post-stroke treatment focuses on secondary prevention and rehabilitation, but few treatments address functional recovery. Creatine, a supplement known for improving physical performance, may aid in the recovery of stroke patients, reducing sarcopenia and improving strength among other effects. This pilot study will investigate the effectiveness of creatine supplementation in enhancing physical and functional recovery in ischemic stroke patients. The study will involve a randomized, double-blind clinical trial comparing creatine monohydrate to a placebo.Read full original descriptionShow less
Effect of Supplementation With Creatine on the Early Recovery of Ischemic Stroke: A Randomized Clinical Trial
Stroke is a leading cause of disability and the second leading cause of death worldwide. Most strokes are ischemic, caused by acute arterial occlusion. Post-stroke treatment focuses on secondary prevention and rehabilitation, but few treatments address functional recovery. Creatine, a supplement known for improving physical performance, may aid in the recovery of stroke patients, reducing sarcopenia and improving strength among other effects. This pilot study will investigate the effectiveness of creatine supplementation in enhancing physical and functional recovery in ischemic stroke patients. The study will involve a randomized, double-blind clinical trial comparing creatine monohydrate to a placebo.
Inclusion: Age between 18 and 80 years; Recent diagnosis of ischemic stroke (from 24 hours to 5 days) ; Neurological deficit due to the stroke that affects mobility (paresis and/or ataxia) and requires motor rehabilitation; Ability to understand and sign the informed consent form, or failing that, have sufficient support to carry out the correct follow-up of the study.
Exclusion: Moderate-severe disability prior to stroke, defined by an mRS>2; Neurological deficit due to stroke that prevents walking without help from another person. The use of support with a cane, crutch or walker is permitted; History of allergic reactions to creatine; Severe kidney disease (GFR <30ml/min/1.73 m2); Unstable or severe clinical situation that prevents active rehabilitation; Moderate or severe dysphagia that makes therapeutic adherence difficult; Use of creatine supplements in the last 3 months, or use of anabolic products in the last 3 months; Musculoskeletal pathology that prevents assessment of muscle strength. For example: fractures, severe osteoarthritis, ligament tears or tendinopathies; Pregnancy or breastfeeding; Simultaneous participation in another clinical trial.