Tests whether aerobic exercise improves memory in people with Parkinson disease
Compares aerobic exercise with stretching for memory in people with Parkinson disease.
Plain-language title generated from the registry record
Registry title: Exploring the Effects of Exercise on Memory and Cognition in Parkinson´s Disease
Key facts
- Where
- Heidelberg, GermanySee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 50 and 80 years old?
Source: NCT06580977, who can take part
Where in Germany
- Heidelberg UniversityHeidelberg, GermanyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Heidelberg University
- Trial code
- NCT06580977
- Record updated
- 30 August 2024
- Original description
The study aims to assess the effects of cardiovascular (aerobic) training on memory formation and cognitive function in people with Parkinson's disease. Participants will be randomly allocated to one of two groups either performing cardiovascular training (experimental group) or stretching (control group) for twelve weeks, three times a week. The primary aim is to examine whether moderate-intense cardiovascular training (MICT) improves procedural memory formation (primary outcome) compared to stretching. Secondary outcomes include episodic memory formation, cognitive function, cardiorespiratory fitness, sleep quality, and brain-derived neurotrophic factor (BDNF) blood concentration levels.Read full original descriptionShow less
Exploring the Effects of Exercise on Memory and Cognition in Parkinson´s Disease
The study aims to assess the effects of cardiovascular (aerobic) training on memory formation and cognitive function in people with Parkinson's disease. Participants will be randomly allocated to one of two groups either performing cardiovascular training (experimental group) or stretching (control group) for twelve weeks, three times a week. The primary aim is to examine whether moderate-intense cardiovascular training (MICT) improves procedural memory formation (primary outcome) compared to stretching. Secondary outcomes include episodic memory formation, cognitive function, cardiorespiratory fitness, sleep quality, and brain-derived neurotrophic factor (BDNF) blood concentration levels.
Inclusion: Diagnosed Parkinson's disease; Disease stage ≤3 on the Hoehn \& Yahr scale; Age ranging from 50 - 80 years; Naive to the memory tasks (primary outcomes); Ability to stand and walk at least 10 meters independently.
Exclusion: Significant level of cognitive impairment (i.e., Montreal Cognitive Assessment <21); Diagnosed psychiatric illness; Known clinically relevant neurological, internal or orthopedic conditions besides Parkinsonism that would interfere with the exercise paradigm; Atypical Parkinsonism; Deep brain stimulation or brain pacemaker; Exceeding the recommended level of cardiovascular exercise for older adults (i.e., cardiovascular exercise done ≥150 min per week of moderate-intensity or ≥75 min per week of vigorous-intensity).