Online Therapy for OCD in Children and Teens With Autism
Tests internet-delivered therapy for obsessive-compulsive disorder in children and teens with autism.
Key facts
- Who runs it
- Karolinska Institutet
- Where
- Gothenburg, Lund, and Stockholm, SwedenSee the 3 sites
- Trial code
- Registry title
- ICBT for OCD in Children With Autism
- Status
- Recruiting
- People taking part
- 220 people, planned
- Started
- 25 Nov 2024
- Expected to end
- Mar 2029
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Internet-delivered exposure and response prevention (I-ERP)
- Internet-delivered stress management (I-SM)
- Record updated
- 14 September 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for children and teenagers aged 7 to 17 who have both autism and obsessive-compulsive disorder (OCD). They take part in online therapy with a parent or caregiver.
- Age
- 7 to 17 years
- Sex
- All sexes can join.
- Disease stage
- Autism diagnosis, plus an OCD diagnosis with a total score of 16 or more on the CY-BOCS.
- Earlier treatment
- Cannot have finished CBT for OCD (at least 5 sessions including ERP) in the last 12 months. Cannot be in other psychological treatment for OCD or anxiety. No start, dose change or stop of OCD medication or of medication for behavioural symptoms of autism in the 6 weeks before the baseline assessment.
Main reasons for not taking part
- Global intellectual disability
- Psychotic disorder, bipolar disorder, severe eating disorder, severe depression, alcohol/substance dependence or hoarding disorder
- Current suicidal intent or a suicide attempt in the last 12 months
- Main symptoms are hoarding symptoms
- Close relationship to a child already in the trial, such as a sibling or cousin
The registry criteria, word for word
Show all 15 criteriaShow less
Who can take part
- A diagnosis of autism, based on the diagnostic criteria of the 4th or 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM) or the 10th edition of the International Classification of Diseases (ICD-10). Informed by the parent/caregiver and subsequently confirmed by review of the medical record or the neurodevelopmental assessment report. A diagnosis of autism will be considered present if it was established with validated instruments, such as the Autism Diagnostic Interview-Revised (ADI-R), the Autism Diagnostic Observation Schedule (ADOS) edition 1 or 2 or the Diagnostic Interview for Social and Communication Disorders (DISCO; autism or ASD cut-offs)
- A DSM-5 diagnosis of OCD. Confirmed by the assessor at the inclusion assessment, based on a structured diagnostic interview
- A total score of ≥16 on the CY-BOCS. Confirmed by the assessor at the inclusion assessment
- Age between 7 and 17 years. Confirmed by the caregiver and subsequently by the medical record system
- Ability to read and write Swedish. Confirmed by the caregiver at the telephone screening or/and the inclusion assessment
- Regular access to a computer or a smartphone/tablet connected to the internet, and a mobile phone to receive text messages. Confirmed by the caregiver at the telephone screening or/and inclusion assessment
- A parent/caregiver able to participate in the treatment alongside their child. Confirmed by the caregiver at the telephone screening or/and the inclusion assessment
Who cannot take part
- Current suicidal intent or a previous suicide attempt within the last 12 months. Confirmed by the assessor at the inclusion assessment and, if required, the medical record
- Completed CBT for OCD within the last 12 months prior to the inclusion assessment (defined as at least 5 sessions of CBT including ERP). Confirmed by the caregiver at the telephone screening or/and inclusion assessment and, if required, the medical record
- Initiation, dosage change or cessation of medication for OCD (primarily selective serotonin reuptake inhibitors, SSRIs) or behavioural symptoms of ASD (atypical antipsychotics) within the 6 weeks prior to the baseline assessment. Confirmed by the caregiver at the telephone screening and the inclusion assessment and, if required, the medical record
- Comorbid psychotic disorder, bipolar disorder, severe eating disorder, severe depression, alcohol/substance dependence or hoarding disorder. Confirmed by the caregiver at the telephone screening and subsequently by the assessor at the inclusion assessment based on the structured diagnostic interview and, if required, the medical record
- Global intellectual disability. Informed by the parent/caregiver and subsequently confirmed by review of the medical record or the neurodevelopmental assessment report, and additionally estimated with the two subtests matrix reasoning and similarities from the Wechsler Intelligence Scale for Children - fifth edition (WISC-V) or Wechsler Adult Intelligence Scale - fourth edition (WAIS-IV)
- Main symptom presentation consists of hoarding symptoms. Confirmed by the assessor at the inclusion assessment
- Simultaneous psychological treatment for OCD or anxiety. Confirmed by the caregiver at the telephone screening and/or inclusion assessment
- Having a close relationship to an already included participant (e.g., sibling, cousin), to avoid being randomised into two different arms, with the risk of information "leaking" between the groups. Confirmed by the caregiver or assessor at the telephone screening and/or at the inclusion assessment
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 7 and 17 years old?
Where in Sweden
- BUP SpecialmottagningGothenburg, SwedenContact: Karin Melin, PhDTaking people
- Forskningsmottagning barn- och ungdomspsykiatri LundLund, SwedenContact: Per Andrén, PhDTaking people
- Child and Adolescent Psychiatry Research CenterStockholm, SwedenContact: David Mataix-Cols, ProfessorTaking people
About the trial
What the trial wants to find out
The purpose of this trial is to evaluate the clinical efficacy, the cost-effectiveness and the effect durability of a therapist-guided, internet-delivered cognitive-behavior therapy intervention for obsessive-compulsive disorder (OCD) in children and adolescents with autism. A process evaluation of the treatment will also be conducted.
The 2 groups in the trial
- Internet-delivered exposure and response prevention (I-ERP)Treatment being tested
A therapist-guided, internet-delivered exposure and response prevention (I-ERP) programme for children and adolescents with OCD and autism.
- Internet-delivered stress management (I-SM)Existing treatment, for comparison
A therapist-guided, internet-delivered stress management (I-SM) programme for children and adolescents with OCD and autism.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Internet-delivered Cognitive-behaviour Therapy for Obsessive- Compulsive Disorder in Children With Autism: A Randomised Controlled Trial
- Plain-language title
- Online Therapy for OCD in Children and Teens With AutismGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT06582225, who can take part
- Record updated
- 14 September 2026