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Online Therapy for OCD in Children and Teens With Autism

Tests internet-delivered therapy for obsessive-compulsive disorder in children and teens with autism.

Key facts

Who runs it
Karolinska Institutet
Where
Gothenburg, Lund, and Stockholm, SwedenSee the 3 sites
Trial code
Registry title
ICBT for OCD in Children With Autism
Status
Recruiting
People taking part
220 people, planned
Started
25 Nov 2024
Expected to end
Mar 2029
Type of study
Interventional, 2 groupsOne group gets an existing treatment, for comparison.
Treatments tested
  • Internet-delivered exposure and response prevention (I-ERP)
  • Internet-delivered stress management (I-SM)
Record updated
14 September 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for children and teenagers aged 7 to 17 who have both autism and obsessive-compulsive disorder (OCD). They take part in online therapy with a parent or caregiver.

Age
7 to 17 years
Sex
All sexes can join.
Disease stage
Autism diagnosis, plus an OCD diagnosis with a total score of 16 or more on the CY-BOCS.
Earlier treatment
Cannot have finished CBT for OCD (at least 5 sessions including ERP) in the last 12 months. Cannot be in other psychological treatment for OCD or anxiety. No start, dose change or stop of OCD medication or of medication for behavioural symptoms of autism in the 6 weeks before the baseline assessment.

Main reasons for not taking part

  • Global intellectual disability
  • Psychotic disorder, bipolar disorder, severe eating disorder, severe depression, alcohol/substance dependence or hoarding disorder
  • Current suicidal intent or a suicide attempt in the last 12 months
  • Main symptoms are hoarding symptoms
  • Close relationship to a child already in the trial, such as a sibling or cousin

The registry criteria, word for word

Show all 15 criteriaShow less

Who can take part

  • A diagnosis of autism, based on the diagnostic criteria of the 4th or 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM) or the 10th edition of the International Classification of Diseases (ICD-10). Informed by the parent/caregiver and subsequently confirmed by review of the medical record or the neurodevelopmental assessment report. A diagnosis of autism will be considered present if it was established with validated instruments, such as the Autism Diagnostic Interview-Revised (ADI-R), the Autism Diagnostic Observation Schedule (ADOS) edition 1 or 2 or the Diagnostic Interview for Social and Communication Disorders (DISCO; autism or ASD cut-offs)
  • A DSM-5 diagnosis of OCD. Confirmed by the assessor at the inclusion assessment, based on a structured diagnostic interview
  • A total score of ≥16 on the CY-BOCS. Confirmed by the assessor at the inclusion assessment
  • Age between 7 and 17 years. Confirmed by the caregiver and subsequently by the medical record system
  • Ability to read and write Swedish. Confirmed by the caregiver at the telephone screening or/and the inclusion assessment
  • Regular access to a computer or a smartphone/tablet connected to the internet, and a mobile phone to receive text messages. Confirmed by the caregiver at the telephone screening or/and inclusion assessment
  • A parent/caregiver able to participate in the treatment alongside their child. Confirmed by the caregiver at the telephone screening or/and the inclusion assessment

Who cannot take part

  • Current suicidal intent or a previous suicide attempt within the last 12 months. Confirmed by the assessor at the inclusion assessment and, if required, the medical record
  • Completed CBT for OCD within the last 12 months prior to the inclusion assessment (defined as at least 5 sessions of CBT including ERP). Confirmed by the caregiver at the telephone screening or/and inclusion assessment and, if required, the medical record
  • Initiation, dosage change or cessation of medication for OCD (primarily selective serotonin reuptake inhibitors, SSRIs) or behavioural symptoms of ASD (atypical antipsychotics) within the 6 weeks prior to the baseline assessment. Confirmed by the caregiver at the telephone screening and the inclusion assessment and, if required, the medical record
  • Comorbid psychotic disorder, bipolar disorder, severe eating disorder, severe depression, alcohol/substance dependence or hoarding disorder. Confirmed by the caregiver at the telephone screening and subsequently by the assessor at the inclusion assessment based on the structured diagnostic interview and, if required, the medical record
  • Global intellectual disability. Informed by the parent/caregiver and subsequently confirmed by review of the medical record or the neurodevelopmental assessment report, and additionally estimated with the two subtests matrix reasoning and similarities from the Wechsler Intelligence Scale for Children - fifth edition (WISC-V) or Wechsler Adult Intelligence Scale - fourth edition (WAIS-IV)
  • Main symptom presentation consists of hoarding symptoms. Confirmed by the assessor at the inclusion assessment
  • Simultaneous psychological treatment for OCD or anxiety. Confirmed by the caregiver at the telephone screening and/or inclusion assessment
  • Having a close relationship to an already included participant (e.g., sibling, cousin), to avoid being randomised into two different arms, with the risk of information "leaking" between the groups. Confirmed by the caregiver or assessor at the telephone screening and/or at the inclusion assessment

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 7 and 17 years old?

Where in Sweden

  • BUP SpecialmottagningGothenburg, SwedenContact: Karin Melin, PhDTaking people
  • Forskningsmottagning barn- och ungdomspsykiatri LundLund, SwedenContact: Per Andrén, PhDTaking people
  • Child and Adolescent Psychiatry Research CenterStockholm, SwedenContact: David Mataix-Cols, ProfessorTaking people

About the trial

What the trial wants to find out

The purpose of this trial is to evaluate the clinical efficacy, the cost-effectiveness and the effect durability of a therapist-guided, internet-delivered cognitive-behavior therapy intervention for obsessive-compulsive disorder (OCD) in children and adolescents with autism. A process evaluation of the treatment will also be conducted.

The 2 groups in the trial

  • Internet-delivered exposure and response prevention (I-ERP)Treatment being tested

    A therapist-guided, internet-delivered exposure and response prevention (I-ERP) programme for children and adolescents with OCD and autism.

  • Internet-delivered stress management (I-SM)Existing treatment, for comparison

    A therapist-guided, internet-delivered stress management (I-SM) programme for children and adolescents with OCD and autism.

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Internet-delivered Cognitive-behaviour Therapy for Obsessive- Compulsive Disorder in Children With Autism: A Randomised Controlled Trial
Plain-language title
Online Therapy for OCD in Children and Teens With AutismGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Fit questions
Built from NCT06582225, who can take part
Record updated
14 September 2026