Testing Forced Exercise Cycling to Aid Movement Recovery After Stroke
Tests forced aerobic cycling with rehab in adults recovering from stroke.
Plain-language title generated from the registry record
Registry title: I-Score: Intensive Stroke Cycling for Optimal Recovery and Economic Value
Key facts
- Where
- Cleveland, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 85 years old?
Source: NCT06585943, who can take part
Where in United States
- Cleveland ClinicCleveland, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- The Cleveland Clinic
- Trial code
- NCT06585943
- Record updated
- 16 September 2026
- Original description
Traditional rehabilitation approaches are time and personnel intensive and costly, and leave ~75% of stroke survivors with residual disability. We propose a clinical trial to determine effects of forced aerobic exercise (FE; i.e., mechanically supplemented) in facilitating upper and lower extremity motor recovery post-stroke in an outpatient rehabilitation setting, to elucidate neural and biochemical substrates of FE-induced motor recovery, and to evaluate cost effectiveness of a FE-centered intervention compared to traditional stroke rehabilitation. The global effect of FE has the potential to enhance recovery in a growing population of stroke survivors in a cost-effective manner, thus accelerating its clinical acceptance.Read full original descriptionShow less
The I-Score (Intensive Stroke Cycling for Optimal Recovery and Economic Value) Trial
Traditional rehabilitation approaches are time and personnel intensive and costly, and leave ~75% of stroke survivors with residual disability. We propose a clinical trial to determine effects of forced aerobic exercise (FE; i.e., mechanically supplemented) in facilitating upper and lower extremity motor recovery post-stroke in an outpatient rehabilitation setting, to elucidate neural and biochemical substrates of FE-induced motor recovery, and to evaluate cost effectiveness of a FE-centered intervention compared to traditional stroke rehabilitation. The global effect of FE has the potential to enhance recovery in a growing population of stroke survivors in a cost-effective manner, thus accelerating its clinical acceptance.
Exclusion: actively undergoing physical or occupational therapy or enrolled in another interventional study; skull hardware (e.g. screws/plates) or prior craniotomies that could shunt current flow altering EEG measures; hospitalization for myocardial infarction, heart failure or heart surgery within 3 months; cardiac arrhythmia; history of multiple strokes; untreated deep vein thrombosis or pulmonary embolus; unstable angina; uncontrolled hypertension; clinically significant neurologic condition/diagnosis other than stroke; recent history of elicit drug or alcohol misuse or significant mental health illness; hypertrophic cardiomyopathy; severe aortic stenosis; implanted pacemaker or defibrillator; dyspnea at rest; significant contractures; anti-spasticity injection within 3 months of enrollment; other contraindication to exercise or EEGs.
Sixty-six individuals with chronic stroke able to provide informed consent who meet the following criteria for inclusion will be recruited from the Cleveland Clinic:; 3-9 months following single ischemic or hemorrhagic stroke confirmed with neuroimaging (ie: first-time stroke); Fugl-Meyer motor score 19-55 in the involved UE; Fugl-Meyer score <34 in the involved LE demonstrating residual hemiparesis; Ambulatory ≥ 20 meters with no more than contact guard assistance; 18-85 years of age.