Tests radiation therapy for hard-to-control heart rhythm problems
Tests radiation to treat ventricular tachycardia in adults after other treatments failed.
Key facts
- Who runs it
- Corewell Health East
- Where
- Royal Oak, United StatesSee the site
- Trial code
- Registry title
- Cardiac Radioablation for VT
- Status
- Not yet recruiting
- People taking part
- 24 people, planned
- Started
- Jul 2026
- Expected to end
- Jan 2028
- Type of study
- Interventional, 3 groups
- Treatments tested
- Stereotactic Body Radiation Therapy (SBRT)
- Record updated
- 20 April 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with ventricular tachycardia (a fast, abnormal heart rhythm) that keeps coming back despite treatment. It tests radiation to the heart.
- Age
- 18 years or older
- Sex
- All sexes
- Disease stage
- Monomorphic ventricular tachycardia with at least two episodes within an eight week (56 day) period recorded by an implanted defibrillator, or heart failure related to VT, or VT storm. Ejection fraction of 20% or more. Likely to live for 12 months without VT.
- Earlier treatment
- At least one previous cardiac ablation for VT. VT must continue despite antiarrhythmic medicines. No prior radiation therapy to the chest or upper abdomen.
Main reasons for not taking part
- Class IV heart failure
- Abandoned leads
- Prior radiation therapy to the chest or upper abdomen
- Interstitial lung disease
- Cannot have a cardiac MRI
The registry criteria, word for word
Show all 14 criteriaShow less
Who can take part
- Participants must be 18 years or older
- Automatic implanted cardiac defibrillator present
- VT is monomorphic with at least two episodes of VT within an eight week (56 day) period as recorded by an AICD or heart failure related to VT or VT storm
- Ejection fraction ≥20%
- At least one previous cardiac ablation for VT
- VT refractory despite antiarrhythmic medications
- Likely to live for 12 months in the absence of VT
- AICD in a position in the chest RT to be given without direct radiation
- Woman of reproductive age must ensure that she won't become pregnant or breastfeed at the time of RT
- The participant has no contraindications to a Cardiac MRI as per routine Cardiology practice
Who cannot take part
- Prior radiation therapy to the chest or upper abdomen
- Class IV heart failure
- Interstitial lung disease
- Abandoned leads
Where in United States
- Corewell Health William Beaumont University HospitalRoyal Oak, United StatesContact: John Robertson, MDNot yet recruiting
About the trial
What the trial wants to find out
The goal of this interventional study is to determine the minimum dose necessary for successful cardiac radioablation of refractory ventricular tachycardia (VT) and to study the utility of target volume definition using Delayed Enhancement Cardiac MRI (DE-CMR) .
The 3 groups in the trial
- Radiation Therapy at 15 Gy for Ventricular TachycardiaTreatment being tested
Post myocardial infarction patients with refractory ventricular tachycardia requiring cardio ablation, treated with 15 Gy
Treatment: Stereotactic Body Radiation Therapy (SBRT)
- Radiation Therapy at 20 Gy for Ventricular TachycardiaTreatment being tested
Post myocardial infarction patients with refractory ventricular tachycardia requiring cardio ablation, treated with 20 Gy
Treatment: Stereotactic Body Radiation Therapy (SBRT)
- Radiation Therapy at 25 Gy for Ventricular TachycardiaTreatment being tested
Post myocardial infarction patients with refractory ventricular tachycardia requiring cardio ablation, treated with 25 Gy
Treatment: Stereotactic Body Radiation Therapy (SBRT)
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- A Phase I/II Study of Cardiac Radioablation for Refractory Ventricular Tachycardia
- Plain-language title
- Tests radiation therapy for hard-to-control heart rhythm problemsGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 20 April 2026