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Testing Heart and Circulation Monitoring Methods in Adults on VV ECMO

Compares methods for checking heart and blood flow in adults on ECMO.

Key facts

Who runs it
Medical University of Vienna
Where
Vienna, AustriaSee the site
Trial code
Registry title
Hemodynamic Monitoring and Fluid Responsiveness in Venovenous Extracorporeal Membrane Oxygenation (VV ECMO) - "HemodynamECMOnitoring-VV Study"
Status
Recruiting
People taking part
30 people, planned
Started
3 May 2024
Expected to end
Jan 2027
Type of study
Interventional
Treatments tested
  • Transthoracic Echocardiography
  • Uncalibrated Pulse Contour Analysis
  • Transpulmonary Thermodilution/Calibrated Pulse Contour Analysis
  • Esophageal Doppler
  • Bioreactance
  • Passive Leg Raising
  • Vena Cava Ultrasound
  • End-expiratory /-inspiratory occlusion test
  • Fluid bolus
Record updated
29 September 2025

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults aged 18 to 75 who are receiving VV-ECMO support. It tests how accurately different methods monitor blood circulation during ECMO.

Age
18 to 75 years
Sex
Men and women can both join.
Earlier treatment
People must be receiving VV-ECMO support.

Main reasons for not taking part

  • Pregnancy
  • Conditions that do not allow passive leg raising, such as an open abdomen, known or suspected raised pressure in the head, recent leg or spine injury, or orthopedic problems that do not allow leg raising
  • Known stroke (blocked or bleeding) within 3 months before joining

The registry criteria, word for word

Show all 5 criteriaShow less

Who can take part

  • Patient receiving VV-ECMO support
  • Age 18 - 75 years

Who cannot take part

  • Known ischemic or hemorrhagic stroke within 3 months prior to study enrollment; Suspicion of raised intracranial pressure is defined as pupil divergence (if not yet further clarified radiographically/neurologically/ophthalmologically) or signs detected in routine computed tomography scans (compressed or elapsed basal cisterns or midline shift \> 5 mm
  • Conditions not allowing for passive leg raising maneuvers, e.g. "open abdomen", known or suspected elevation of intracranial pressure, recent leg or spinal trauma or orthopedic conditions not permitting leg raising
  • Pregnancy

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 75 years old?

Where in Austria

  • Medical University of ViennaVienna, AustriaContact: Thomas Staudinger, MDTaking people

About the trial

What the trial wants to find out

In extracorporeal membrane oxygenation (ECMO), blood is drawn out of the body via tubes, oxygenated in an artificial lung; and then pumped back into the blood vessels. This allows the supply of oxygen-rich blood to the organs (brain, heart, lungs, kidneys, liver, intestines, etc.) to be maintained.

Read full original descriptionShow less

Continuous monitoring of cardiac function and circulatory status (blood pressure, blood flow to organs) is very important in intensive care medicine in order to control the administration of circulation-supporting medication and infusions. Various devices are routinely used for this task. However, in the specific situation of ECMO treatment, the measurements of these devices could be affected due to the artificial circulation; outside the body.

The purpose of this study is therefore to test the accuracy of different methods of circulation monitoring during ECMO treatment.

The group in the trial

  • Entire Study PopulationTreatment being tested

    The entire study population will undergo serial hemodynamic assessments throughout the course of ECMO therapy. Hemodynamic variables are obtained using transthoracic echocardiography, uncalibrated pulse contour analysis, and optionally - depending on device availability - transpulmonary thermodilution, bioreactance and esophageal doppler. Maneuvers for assessing volume responsiveness include passive leg raising (PLR), respiratory pulse pressure variation (PPV), stroke volume variation (SVV), inferior vena cava ultrasound (IVC), and end-inspiratory or end-expiratory occlusion tests.

    Treatment: Transthoracic Echocardiography, Uncalibrated Pulse Contour Analysis, Transpulmonary Thermodilution/Calibrated Pulse Contour Analysis, Esophageal Doppler, Bioreactance, Passive Leg Raising, Vena Cava Ultrasound, End-expiratory /-inspiratory occlusion test, and Fluid bolus

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Validation of Techniques for Hemodynamic Monitoring and Prediction of Fluid Responsiveness in Patients Undergoing Venovenous Extracorporeal Membrane Oxygenation - A Prospective Diagnostic Accuracy Study ("HemodynamECMOnitoring-VV Study")
Plain-language title
Testing Heart and Circulation Monitoring Methods in Adults on VV ECMOGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Fit questions
Built from NCT06593717, who can take part
Record updated
29 September 2025