Personalized Digital Training Intervention to Reduce Inflammation by Correcting Pathological Movement Patterns in Pre-stage Knee Osteoarthritis After Anterior Cruciate Ligament Reconstruction
Key facts
- Where
- Berlin, GermanySee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 50 years old?
Source: NCT06596824, who can take part
Where in Germany
- Charité - Universitätsmedizin Berlin, BeMoveD - Berlin Movement DiagnosticsBerlin, GermanyContact: Winkler, Prof. Dr.med.Taking people
- Charité Universitätsmedizin BerlinBerlin, GermanyContact: Winkler, Prof.Dr.med.Taking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Charite University, Berlin, Germany
- Trial code
- NCT06596824
- Record updated
- 2 March 2026
- Original description
Osteoarthritis (OA) is a condition that causes pain and stiffness in the joints, often due to injuries like torn ligaments. Even after surgery, these injuries can lead to long-term joint problems. Current treatments don\'t fully prevent OA from developing. This study is testing a new 12-week exercise program designed to improve how the knee moves, using a special sensor-based system. The goal is to reduce joint inflammation and prevent the development of OA in patients who have had knee surgery.Read full original descriptionShow less
Personalized Digital Training Intervention to Reduce Inflammation by Correcting Pathological Movement Patterns in Pre-stage Knee Osteoarthritis (OA)
Osteoarthritis (OA) is a condition that causes pain and stiffness in the joints, often due to injuries like torn ligaments. Even after surgery, these injuries can lead to long-term joint problems. Current treatments don\'t fully prevent OA from developing. This study is testing a new 12-week exercise program designed to improve how the knee moves, using a special sensor-based system. The goal is to reduce joint inflammation and prevent the development of OA in patients who have had knee surgery.
Inclusion: Signed written informed consent; Adult subjects between 18 to 50 years old at the time of screening; Primary ACL reconstruction within a maximum of 6 months after a unilateral ACL injury; Complete baseline assessment between 8 and 12 weeks after ACL reconstruction.
Exclusion: Significant trauma to a weight-bearing joint within 12 months prior to study initiation (excluding the ACL injury); Previous surgeries on the study knee (except for the ACL reconstruction); Contraindications for MRI, including pacemakers, defibrillators, metal implants, pregnancy, sensorineural hearing loss above 30 dB, tinnitus and claustrophobia; Currently enrolled in or has not yet completed a period of at least 5 times as the half-life time of the drug used in the previous trial since ending other investigational device or drug trial(s); Immunosuppression due to illness or medication; Sepsis or hemostasis disorders; Severe uncontrolled inflammatory disease or autoimmune disease (e.g., ulcerative colitis, Crohn's disease, etc.); Having malignancy and undergoing treatment including chemotherapy, radiotherapy, or immunotherapy; Any form of substance abuse, psychiatric disorder, or other condition that, in the opinion of the Investigator, may invalidate communication with the Investigator and/or designated study personnel; Signs of knee OA as defined by the OARSI-Joint Space Narrowing (JSN) Score of two or more (standing AP x-ray); Physical activity level: Tegner activity score before injury of 0-2 (very low activity) or 8-10 (very high activity); Body mass index ≥ 30 kg/m2; Inflammatory arthropathies; Unable to freely give their informed consent (e.g., individuals under legal guardianship); Patients who are dependent on the sponsor, investigator, or study site; Pregnant or breast-feeding women or women of childbearing potential not protected by an effective contraceptive method of birth control (defined as pearl index < 1); Patients who are committed to an institution by virtue of an order issued by either the judicial or the administrative authorities.