Baker Cyst Aspiration Combined With Platelet-rich Plasma Injection in Knee Osteoarthritis
Key facts
- Who runs it
- Izmir Katip Celebi University
- Where
- Türkiye1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 32 people enrolled
- Started
- 15 Sept 2024
- Ended
- 19 Aug 2025
- Type of study
- Interventional, 2 groupsOne group gets no study treatment, for comparison.
- Treatments tested
- Platelet Rich Plasma
- Record updated
- 26 August 2025
Who can take part
- Age
- 18 years to 75 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
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Who can take part
- Diagnosis of grade 1-2-3 knee osteoarthritis according to Kellgren Lawrence classification
- Presence of a baker cyst (popliteal cyst) with at least one of the width or length measurements \>1 cm (proven by magnetic resonans imaging or muskuloskeletal ultrasound examination)
Who cannot take part
- Long-term use (more than 3 months) of corticosteroid-containing medication
- History of previous knee surgery
- Presence of secondary causes other than gonarthrosis which may lead to the development of a Baker cyst, such as meniscopathy, rheumatic diseases or anterior cruciate ligament damage, etc
- History of hyaluronic acid injection into the knee within the last 6 months or corticosteroid injection within the last 3 months
- Immunologic or connective tissue disease
- History of pregnancy or breastfeeding
- Current Hb value \<12 or platelet value \<150,000
- Patients with grade 4 knee osteoarthritis according to the Kellgren Lawrence classification
- Skin lesions in and around the knee area in the last 7 days
- Patients with lateral knee joint space narrowing more than medial
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
Enlargement of any bursa in or around the popliteal fossa (most commonly the gastrocnemio-semimembranosus (GS) bursa) is called a Baker cyst (BC). Common clinical manifestations of BCs are swelling, mass, pain or stiffness, usually worsening with activity. There may be swelling and tightness or pain behind the knee when walking. However, the majority of these cysts are asymptomatic. They can be detected incidentally in the general population but are more commonly found in patients with osteoarthritis of the knee.
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In previous studies, aspiration or corticosteroid treatment was frequently used to treat baker's cysts in patients with osteoarthritis and meniscal or ligamentous injuries. However, there is no previous study in the literature showing the efficacy of PRP injection in baker's cyst. In our study, we aimed to compare the efficacy of cyst aspiration and PRP injection into the cyst on pain, function and cyst size compared to cyst aspiration.
The 2 groups in the trial
- Aspiration groupNo study treatment, for comparison
The existing Baker's cyst of patients in this group will be aspirated under ultrasonographic guidance.
- PRP+Aspiration groupTreatment being tested
The existing Baker's cyst of patients in this group will be aspirated under ultrasonography guidance and PRP injection will be administered into the cyst.
Treatment: Platelet Rich Plasma
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Ultrasound-guided Baker Cyst Aspiration Combined With Platelet-rich Plasma Injection in Knee Osteoarthritis: a Randomised Clinical Trial
- Record updated
- 26 August 2025