Studying fungi that may drive psoriasis inflammation in people
Studies fungal immune signals in adults with psoriasis, a chronic skin disease.
Plain-language title generated from the registry record
Registry title: Characterization of the Fungal Immunopeptidome Involved in the Immunopathological Mechanisms of Psoriasis
Key facts
- Where
- Paris, FranceSee the site
Where in France
- Service de Parasitologie-Mycologie Hôpital St AntoineParis, FranceNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Assistance Publique - Hôpitaux de Paris
- Trial code
- NCT06610942
- Record updated
- 26 August 2025
- Original description
Psoriasis is a chronic immune-mediated skin disorder characterized by inflammatory cutaneous plaques and, occasionally, arthritis, affecting 60 million adults and children worldwide. Although a variety of treatments have been developed aimed to relieve the associated symptoms, there is yet no permanent cure for psoriasis. TH17 type immunity, via the production of IL-17A and other pro-inflammatory cytokines, are considered to play a central role in the pathogenesis of this disease. Moreover, experimental evidence obtained in animal models, points to human mycobiota as a trigger for the initiation and/or progression of psoriasis. Therefore, human studies are required to better characterize the major fungi implicated in the local and systemic inflammatory responses, as well as to determine the immunopeptidome that shapes the pathogenic T cell receptor repertoire.Read full original descriptionShow less
Characterization of the Fungal Immunopeptidome Involved in the Immunopathological Mechanisms of Psoriasis
Psoriasis is a chronic immune-mediated skin disorder characterized by inflammatory cutaneous plaques and, occasionally, arthritis, affecting 60 million adults and children worldwide. Although a variety of treatments have been developed aimed to relieve the associated symptoms, there is yet no permanent cure for psoriasis. TH17 type immunity, via the production of IL-17A and other pro-inflammatory cytokines, are considered to play a central role in the pathogenesis of this disease. Moreover, experimental evidence obtained in animal models, points to human mycobiota as a trigger for the initiation and/or progression of psoriasis. Therefore, human studies are required to better characterize the major fungi implicated in the local and systemic inflammatory responses, as well as to determine the immunopeptidome that shapes the pathogenic T cell receptor repertoire.
We will explore the hypothesis that commensal fungi could participate in the chronic inflammatory immune response underlying the pathogenesis of human psoriasis via the recognition of cutaneous fungal antigens and/or via a gut-skin mycobiome cross-reactive mechanism
Inclusion: Adults with psoriasis failing local treatment. Adults requiring reconstructive plastic surgery (resident skin immunology checks); Adults living in the same household as a patient suffering from psoriasis (intestinal mycobiome checks).
Exclusion: Minors Individuals under legal protection. Pregnant or breastfeeding women.