Ultrasound of Nerves in Guillain-Barré Syndrome and CIDP
Studies nerve ultrasound scans against nerve tests in people with Guillain-Barré syndrome or CIDP.
Plain-language title generated from the registry record
Registry title: Our Study Aims to Determine if Nerve Alterations in Acute GBS and CIDP Detectable by Ultrasound Match Electrodiagnostic Findings and if This Method Aids Early Diagnosis, Predict Their Outcomes and Differentiate Between Axonal and Demyelinating Subtypes.
Key facts
- Where
- Asyut, EgyptSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT06615622, who can take part
Where in Egypt
- Assiut university HospitalsAsyut, EgyptTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Assiut University
- Trial code
- NCT06615622
- Record updated
- 3 October 2025
- Original description
Neuromuscular ultrasound (NMUS) is emerging as a valuable non-invasive diagnostic tool. In GBS, NMUS can detect proximal nerve enlargement early, before neurophysiological changes. Persistent nerve enlargement can be observed up to 15 years, though its correlation with disability varies. Research is needed to clarify NMUS findings in GBS and CIDP over time. Early detection of nerve root enlargement via NMUS could facilitate earlier diagnosis and intervention, improving patient outcomes and understanding of these conditions\' pathophysiology.Read full original descriptionShow less
A Comparative Study of Peripheral Nerve Ultrasound Findings in Immune Mediated Peripheral Nerve Disorders; a Hospital-based Study
Neuromuscular ultrasound (NMUS) is emerging as a valuable non-invasive diagnostic tool. In GBS, NMUS can detect proximal nerve enlargement early, before neurophysiological changes. Persistent nerve enlargement can be observed up to 15 years, though its correlation with disability varies. Research is needed to clarify NMUS findings in GBS and CIDP over time. Early detection of nerve root enlargement via NMUS could facilitate earlier diagnosis and intervention, improving patient outcomes and understanding of these conditions\' pathophysiology.
This study aims to determine if nerve alterations in acute GBS and CIDP detectable by ultrasound match electrodiagnostic findings and if this method aids early diagnosis. The investigators will perform serial nerve ultrasounds and NCS to investigate nerve morphology, predict outcomes, and differentiate between axonal and demyelinating subtypes.
Inclusion: Diagnosis of patient group:; GBS Patients: Diagnosed according to the criteria of the National Institute of Neurological Disorders and Stroke (NINDS) and the Brighton Collaboration (2011); CIDP Patients: Diagnosed according to the criteria of the European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS); Age: Participants aged 18 to 75 years; Onset:; GBS Patients: Recent onset of GBS within the first 2 weeks of symptom onset; CIDP Patients: Either relapsing or progressive course consistent with CIDP diagnosis; Gender: Both male and female participants are eligible; Participation: Willingness to participate in the study, including undergoing disease-related examinations and assessments; Consent: Ability and willingness to provide informed consent.
Exclusion: Patients with metabolic disorders or malignancies; Patients unable or unwilling to provide informed consent; Patients with other causes of peripheral neuropathy; Patients with other causes of acute flaccid paralysis.