Tests acceptance and commitment therapy with ketamine for alcohol use and depression

Trial details

Who runs it

Centre hospitalier de l'Université de Montréal (CHUM)

Trial code

NCT06620276

Record updated

5 March 2026

Original description

Alcohol use disorders (AUDs) and depressive disorders frequently coexist, complicating the clinical management of patients suffering from them.Read full original descriptionShow less

Acceptance and Commitment Therapy in Patients With Alcohol Use Disorder and Comorbid Treatment-Resistant Depression Who Are Undergoing Ketamine Intervention: A Feasibility Study

Alcohol use disorders (AUDs) and depressive disorders frequently coexist, complicating the clinical management of patients suffering from them.

Taken separately, these two disorders have a significant prevalence in the population, and a recent meta-analysis concluded that coexistence could reach 1 in 5 patients (20.8%). This comorbidity represents a considerable challenge, particularly in cases of treatment-resistant depression (TRD), where patients do not respond to conventional pharmacological interventions.

Since alcohol can act as a powerful trigger for depressive symptoms, and conversely, a depressive state increases the risk of alcohol abuse, the question of intervention sequence is also of clinical interest: should priority be given to treating TRD, AUD or both simultaneously? This question raises a major issue for healthcare professionals, as current conventional therapeutic approaches present limitations in the concomitant management of these complex disorders.

Thus, in certain clinical settings, ketamine has emerged as a promising intervention to treat both TRD and AUD. In fact, ketamine has been shown to produce rapid but only transient antidepressant effects, and is part of the possible treatment arsenal for TRD. The potential of ketamine in the treatment of AUD has also been explored in recent studies, with a few small randomized controlled trials. In these trials, the combination of ketamine with psychotherapy, versus placebo, was investigated as a means of alleviating AUD. Ketamine was shown to increase abstinence rates, time to relapse and decrease the number of heavy drinking days.

Acceptance and Commitment Therapy (ACT) is a form of cognitive-behavioural therapy that emphasizes psychological flexibility and acceptance of difficult emotions and thoughts without judgment, a type of psychotherapy particularly relevant to AUD. Thus, adding ACT to ketamine treatment could increase the duration of ketamine's effect on depressive symptoms, while reducing AUD.

In view of this accumulated evidence of the potential benefit of ketamine and ACT, adding acceptance and commitment therapy to ketamine appears to be a promising option for improving outcomes in patients diagnosed with TRD comorbid with AUD. This study will not only verify the feasibility of this type of intervention in this particular patient population, but also the preliminary effects on their alcohol consumption and depressive symptoms.

Inclusion: Provision of written informed consent after reading and understanding the patient information handout; Alcohol Use Disorder (AUD) diagnosed by a trained psychiatrist; Diagnosis of treatment resistant unipolar or bipolar depression, defined as failure to respond to ≥2 adequate trials per Canadian national depression guidelines; Willingness to engage in 8 weekly psychotherapy sessions; No changes to psychotropic medications during treatment; Average daily ethanol consumption of at least moderate risk as per WHO risk levels (Men: >40 to 60 g per day or >2.9 to 4.3 drinks / Women: >20 to 40 g per day or >1.4 to 2.9 drinks); Bipolar or unipolar depressive episode (DSM5), current episode, with MADRS ≥ 20; Age 18 to 70 years; Agreement to abstain from consuming grapefruit juice on ketamine infusion days; Agreement to abstain from driving or operating heavy machinery after infusions until the next day.

Exclusion: Current or prior substance abuse or dependence other than AUD (except caffeine or nicotine); Positive toxicology screen for drugs not prescribed; Current participation in other evidence based psychotherapeutic interventions for mood disorders or substance abuse; Psychiatric comorbidity likely to take precedence over AUD or TRD; Acute psychotic disorder or acute psychotic symptoms; Known intellectual disability or autism spectrum disorder; Depression secondary to stroke, cancer, or severe medical conditions; Risk factors for intracranial hemorrhage (trauma, aneurysm, neurosurgery); Uncontrolled hypertension or significant coronary or cerebrovascular disease; Renal or hepatic impairment; Any unstable or clinically significant condition judged by the study physician to interfere with treatment; Known intolerance or hypersensitivity to ketamine; Significant hearing impairment not improved by aids; Abnormal liver function tests (AST or ALT ≥ 3 times upper normal limit); Inability to commit to the study protocol due to professional or personal obligations; Non English or non French speaking; Non response to esketamine or ketamine during the current depressive episode; Inability to attend regular visits to the CHUM Neuromodulation clinic; Pregnant, lactating, or of childbearing potential without approved contraception use during ketamine treatment, with a negative urine pregnancy test required at baseline; Clinically significant abnormal ECG results; Unstable thyroid hormone levels or uncorrected hypo or hyper thyroidism; Unwillingness to abstain from benzodiazepines, narcotics, or NMDA antagonists (including memantine and lamotrigine) 12 hours before infusions; Any recent significant decline in exercise tolerance.

ClinicalTrials.gov NCT06620276