Comparing two heart pacing methods in people with atrial fibrillation and weak heart pumping
Compares two heart pacing methods in adults with atrial fibrillation and weakened heart function.
Plain-language title generated from the registry record
Registry title: Left Bundle Branch Area Pacing or Biventricular Pacing in AF and Left Ventricular Dysfunction
Key facts
- Where
- Aarhus N, DenmarkSee the site
Where in Denmark
- Aarhus University HospitalAarhus N, DenmarkNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- srdpiers
- Trial code
- NCT06620705
- Record updated
- 1 October 2024
- Original description
It is unknown whether left bundle branch area pacing (LBBAP) or biventricular pacing best prevents or reverses left ventricular (LV) adverse remodelling in patients with atrial fibrillation (AF) who require ventricular pacing or CRT. This randomized non-inferiority cross-over trial will compare left ventricular end-systolic volume change and secondary endpoints between LBBAP and biventricular pacing in patients with AF and LV dysfunction.Read full original descriptionShow less
Pacing Away from Heart Failure: Left Bundle Branch Area Pacing or Biventricular Pacing in Patients with Atrial Fibrillation and Left Ventricular Dysfunction
It is unknown whether left bundle branch area pacing (LBBAP) or biventricular pacing best prevents or reverses left ventricular (LV) adverse remodelling in patients with atrial fibrillation (AF) who require ventricular pacing or CRT. This randomized non-inferiority cross-over trial will compare left ventricular end-systolic volume change and secondary endpoints between LBBAP and biventricular pacing in patients with AF and LV dysfunction.
Inclusion: In order to be eligible to participate in this study, a subject must meet all of the following criteria:; Adults ≥18 years with permanent AF and LVEF \< 50% who either require ventricular pacing because of bradycardia including patients undergoing AV junction ablation, or have an indication for cardiac resynchronization therapy; Expected percentage of ventricular pacing \> 40%; ≥ 3 months of heart failure medication optimization; Of note, patients who already have a device, but require an upgrade to a CRT device, can also be included.
Exclusion: Recent valve intervention/surgery or acute myocardial infarction (\< 6 months); NYHA functional class IV heart failure, left ventricular assist device or cardiac transplant; Age \< 18 years; A potential subject who meets any of the following criteria will be excluded from participation in this study:; Pregnancy or active pregnancy wish; Not eligible for implantation of an RV lead, LBBAP lead, or LV lead in the coronary sinus.