Exercise Program to Improve Walking in People With Kidney and Leg Artery Disease
Tests a walking exercise program in adults with chronic kidney disease and peripheral artery disease.
Plain-language title generated from the registry record
Registry title: Exercise Activity to Improve Mobility in Patients With CKD and PAD
Key facts
- Where
- Ferrara, Peschiera del Garda, and Reggio Calabria, ItalySee the 3 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT06621264, who can take part
Where in Italy
- University Hospital Of FerraraFerrara, ItalyTaking people
- Ospedale Pederzoli Peschiera del GardaPeschiera del Garda, ItalyTaking people
- Grande Ospedale Metropolitano Bianchi Melacrino MorelliReggio Calabria, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital of Ferrara
- Trial code
- NCT06621264
- Record updated
- 31 May 2025
- Original description
People affected by chronic kidney disease and concomitant diagnosed peripheral artery disease at intermediate stages, without contraindications to exercise therapy will be invited to participate in the study.Read full original descriptionShow less
EXercise ACTivity to Improve Mobility, Active Behavior and Quality of Life of Chronic Kidney Disease Patients With Peripheral Artery Disease: the EXACTckd-pad Multicenter Randomized Controlled Trial
People affected by chronic kidney disease and concomitant diagnosed peripheral artery disease at intermediate stages, without contraindications to exercise therapy will be invited to participate in the study.
Whose providing informed consent, will be randomly assigned to one of two groups:
1. Exercise program receiving two daily 10-minute interval walking sessions at a slow increasing speed. 2. Control group: receiving usual care including optimal medical therapy and nutritional advice.
Patients of both groups will be measured at baseline, after the end of the exercise program (6-month) and at follow up (12-month). Outcome measures will include walking ability by the 6-minute walking test (primary outcome) and lower limbs perfusion, body composition, quality of life, laboratory outcomes and long-term hospitalizations.
Inclusion: chronic kidney disease at KDOQI stages III or IV and concomitant Peripheral artery disease at stages I, II, III; ability to walk independently; cognitive function to give informed consent identified by a Mini Mental Status Examination score greater or equal to 20/30; absence of clinical conditions contraindicating exercise therapy (e.g., unstable angina, severe heart failure at NYHA class IV, anemia with lower than 10.0 g/dl).
Exclusion: major surgery planned in the next 3 months; known comorbid conditions that may limit survival to less than 2 years; major amputations; inability or unwillingness to comply with protocol requirements.