Studies how steady sleep affects blood sugar and heart risk in type 1 diabetes
Tests a steady sleep routine in adults with type 1 diabetes.
Plain-language title generated from the registry record
Registry title: Circadian Mechanisms, Glucose, and CV Risks in T1D
Key facts
- Where
- Chicago, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 50 years old?
Source: NCT06624046, who can take part
Where in United States
- University of Illinois ChicagoChicago, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Illinois Chicago
- Trial code
- NCT06624046
- Record updated
- 30 June 2026
- Original description
People with type 1 diabetes are disproportionately affected by cardiovascular disease (CVD). Short and irregular sleep have been associated with cardiovascular risk in this population. Improving sleep regularity has been associated with improved glycemic markers however mechanisms by which improving sleep regularity improves metabolic and cardiovascular health is not known. The investigators propose to conduct a mechanistic study using a sleep stability manipulation. This proposal will advance the understanding of mechanisms by which improving sleep regularity influences glycemic control and cardiovascular risk in T1D.Read full original descriptionShow less
Circadian Mechanisms of Glycemic Control and Cardiovascular Risk in Adults With Type 1 Diabetes
People with type 1 diabetes are disproportionately affected by cardiovascular disease (CVD). Short and irregular sleep have been associated with cardiovascular risk in this population. Improving sleep regularity has been associated with improved glycemic markers however mechanisms by which improving sleep regularity improves metabolic and cardiovascular health is not known. The investigators propose to conduct a mechanistic study using a sleep stability manipulation. This proposal will advance the understanding of mechanisms by which improving sleep regularity influences glycemic control and cardiovascular risk in T1D.
Inclusion: Adults 18-50 years with a clinical diagnosis of T1D for at least one year; Report habitual sleep irregularity ≥1 hour/week; Desire to improve sleep, and own a smartphone (Android or iPhone).
Exclusion: history of restless leg syndrome; history of severe hypoglycemia (defined as hypoglycemic episode that results in loss of consciousness, seizure, or requiring emergency room visit or hospitalization) within the past 6 months; use of sleep medications/aids, significant medical comorbidities (such as heart failure, cirrhosis, chronic obstructive pulmonary disease requiring oxygen, active treatment for cancer, on renal replacement therapy [dialysis]); history of stroke with neurological deficits; Allergy to lidocaine Participants who passed the first screen by phone will be scheduled for a consenting visit at UIC; pregnant, breast feeding, or planning pregnancy, as sleep and glucose are known to change during pregnancy and breastfeeding; Self-reported A1C within the past 6 months ≥10%; insomnia symptoms defined as Insomnia Severity Index score ≥15; rotating shift or night work or routinely sleeping after 3 AM; depression (Patient Health Questionnaire 8 [PHQ-8] score ≥15).