Studying How Viruses Trigger Flare-Ups in Chronic Lung Disease
Follows adults with chronic lung disease, sampling them when well and during flare-ups.
Plain-language title generated from the registry record
Registry title: Exploring How Viral Infections Affect People With Chronic Lung Disease
Key facts
- Where
- London, United KingdomSee the site
Where in United Kingdom
- Royal Brompton HospitalLondon, United KingdomTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Imperial College London
- Trial code
- NCT06625944
- Record updated
- 14 July 2025
- Original description
Many people with chronic lung disease have disease flare-ups. It was previously believed that these were mainly caused by bacteria but recent evidence suggests that viruses could be an important trigger. This study will recruit volunteers with chronic lung disease and take samples both when well (at baseline) and during flare-ups (exacerbations) to better understand the role of viruses in triggering exacerbations and also how the immune response is affected. The researchers will follow the volunteers\' progress for up to two years. Whenever they get unwell they will take some samples (nose swabs, finger prick testing, phlegm sample) and post them to the researchers. Then, they will come in for a visit for more samples (blood tests, further swabs) and a review.Read full original descriptionShow less
Prospective Cohort Study to Understand Impact of Viral Infection in Chronic Lung Disease
Many people with chronic lung disease have disease flare-ups. It was previously believed that these were mainly caused by bacteria but recent evidence suggests that viruses could be an important trigger. This study will recruit volunteers with chronic lung disease and take samples both when well (at baseline) and during flare-ups (exacerbations) to better understand the role of viruses in triggering exacerbations and also how the immune response is affected. The researchers will follow the volunteers\' progress for up to two years. Whenever they get unwell they will take some samples (nose swabs, finger prick testing, phlegm sample) and post them to the researchers. Then, they will come in for a visit for more samples (blood tests, further swabs) and a review.
Inclusion: Adults with a physician confirmed diagnosis of chronic airway disease (e.g. COPD and bronchiectasis) according to established diagnostic criteria; AND; Prior history of exacerbation within last year (defined as requiring antibiotic and/or corticosteroids).
Exclusion: Inability to complete daily symptom diaries and/or attend for clinical assessments; Exacerbation within 4 weeks of study recruitment and/or clinical instability at the time of recruitment; Pregnancy.