Studying How Viruses Trigger Flare-Ups in Chronic Lung Disease

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with long-term lung disease such as COPD or bronchiectasis who had a flare-up in the last year. It studies how viruses trigger flare-ups.

Age

18 Years and older

Sex

All sexes can join.

Disease stage

Chronic airway disease (for example COPD and bronchiectasis) confirmed by a doctor.

Earlier treatment

At least one flare-up in the last year that needed antibiotics and/or corticosteroids.

Main reasons for not taking part

• Cannot complete daily symptom diaries or attend clinical assessments
• Flare-up within 4 weeks of joining the study
• Clinical instability at the time of joining
• Pregnancy

The registry criteria, word for word

What the trial wants to find out

Many people with chronic lung disease have disease flare-ups. It was previously believed that these were mainly caused by bacteria but recent evidence suggests that viruses could be an important trigger. This study will recruit volunteers with chronic lung disease and take samples both when well (at baseline) and during flare-ups (exacerbations) to better understand the role of viruses in triggering exacerbations and also how the immune response is affected. The researchers will follow the volunteers\' progress for up to two years. Whenever they get unwell they will take some samples (nose swabs, finger prick testing, phlegm sample) and post them to the researchers. Then, they will come in for a visit for more samples (blood tests, further swabs) and a review.