Comparing two imaging scans for prostate cancer screening in men
Compares a new ultrasound scan with MRI to see which better images the prostate.
Key facts
- Who runs it
- University of Alberta
- Where
- Martigues, FranceSee the siteAlso in 4 other countries, 8 sites
- Trial code
- Registry title
- Screening for Prostate Cancer Using High Resolution Micro-ultrasound Versus Multiparametric Magnetic Resonance Imaging.
- Status
- Recruiting
- Phase
- Phase 3
- People taking part
- 1,284 people, planned
- Started
- 8 May 2025
- Expected to end
- 30 Nov 2029
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- MRI
- ExactVu
- Record updated
- 25 September 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for men aged 50 to 70 who have never had a prostate biopsy and have a raised PSA level or an abnormal rectal exam.
- Age
- 50 to 70 years
- Sex
- Men only
- Earlier treatment
- No prostate biopsy before. No earlier prostate imaging with microUS or MRI. No testosterone replacement therapy or androgen deprivation therapy in the last 12 months.
- Biomarker or test result
- PSA 3-20 and/or an abnormal DRE (digital rectal exam).
Main reasons for not taking part
- Earlier personal history of prostate cancer
- Earlier prostate imaging with microUS or MRI
- A reason that rules out microUS or MRI
- Testosterone replacement therapy in the last 12 months
- Androgen deprivation therapy in the last 12 months
The registry criteria, word for word
Show all 9 criteriaShow less
Who can take part
- Male sex
- Age 50-70
- PSA 3-20 and/or abnormal DRE
- Biopsy naïve
Who cannot take part
- Prior personal history of prostate cancer
- Prior prostate imaging using microUS or MRI
- Testosterone replacement therapy within last 12 months; or
- Androgen deprivation therapy within last 12 months
- Contraindication to microUS or MRI
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 50 and 70 years old?
Where in France
Also in 4 other countries, 8 sites
- CH de MartiguesMartigues, FranceContact: Gwladys M-Bou, MDTaking people
About the trial
What the trial wants to find out
The purpose of this study is to compare whether the FDA and Health Canada approved microUS is as effective as the currently used option (MRI) for imaging the prostate gland. Participants will be randomized into two groups to compare the imaging results of the current standard of care MRI and the new microUS. The study is looking to identify the most effective imaging modality to help guide whether you progress to have a prostate biopsy.
The 2 groups in the trial
- MRIExisting treatment, for comparison
- microUltransoundTreatment being tested
Treatment: ExactVu
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- A Phase 3, Multicenter, International, Non-inferiority, Randomized Clinical Trial Comparing Screening for Prostate Cancer Using High Resolution Micro-ultrasound Versus Multiparametric Magnetic Resonance Imaging (MUSIC-Screen)
- Plain-language title
- Comparing two imaging scans for prostate cancer screening in menGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT06626022, who can take part
- Publications
- Record updated
- 25 September 2026