Testing longer sleep and body clock timing in teens with type 1 diabetes
Tests extra sleep and melatonin with light therapy in teens with type 1 diabetes.
Plain-language title generated from the registry record
Registry title: Type 1 Diabetes REst for Metabolic Health
Key facts
- Where
- Aurora, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 14 and 19 years old?
Source: NCT06627504, who can take part
Where in United States
- Children's Hospital ColoradoAurora, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Colorado, Denver
- Trial code
- NCT06627504
- Record updated
- 3 June 2026
- Original description
Research has shown a link between poor sleep health and late circadian timing with cardiometabolic health in adolescents with type 1 diabetes (T1D). Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in T1D, which begins as early as adolescence, and current therapies are limited. Therefore, this study plans to investigate whether cardiometabolic health can be improved with increased sleep duration and advanced circadian timing in adolescents with T1D with habitually insufficient sleep. To answer this question, investigators will study adolescents with T1D who get \<7h sleep on school nights and measure changes in insulin sensitivity, glycemic control, and vascular function after one month of a sleep and circadian intervention (1+ hour longer time in bed each night plus evening melatonin and morning light therapy) compared to one month of typical sleep (usual school schedule).Read full original descriptionShow less
Mechanisms Underlying the Relationship Between Sleep and Circadian Health and Cardiometabolic Risk in Adolescents With Type 1 Diabetes
Research has shown a link between poor sleep health and late circadian timing with cardiometabolic health in adolescents with type 1 diabetes (T1D). Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in T1D, which begins as early as adolescence, and current therapies are limited. Therefore, this study plans to investigate whether cardiometabolic health can be improved with increased sleep duration and advanced circadian timing in adolescents with T1D with habitually insufficient sleep. To answer this question, investigators will study adolescents with T1D who get \<7h sleep on school nights and measure changes in insulin sensitivity, glycemic control, and vascular function after one month of a sleep and circadian intervention (1+ hour longer time in bed each night plus evening melatonin and morning light therapy) compared to one month of typical sleep (usual school schedule).
Inclusion: High school students between the ages of 14-19 years; Diagnosed with T1D for ≥1 year; Using an insulin pump or other automated insulin delivery system; Have typically insufficient sleep, defined by ≤ 7 h per night on school days (assessed by actigraphy); With or at risk for obesity based on either above-average weight (BMI ≥50th percentile) or parental history of obesity (BMI ≥ 30 kg/m2); Tanner stage 4 or 5, based on breast development for girls and testicular size for boys.
Exclusion: Prior diagnosis of a sleep disorder (e.g., insomnia, obstructive sleep apnea) or an elevated screening score on the OSA subscale of the Sleep Disorders Inventory for Students-Adolescents measure; Regular use of medications affecting sleep (e.g., stimulants, atypical antipsychotics, melatonin or other sleep aids); Regular use of medications affecting IR (systemic steroids, adjunctive diabetes medications); Severe illness or DKA within 60 days; IQ<70 or severe mental illness impacting sleep or ability to participate in the study; HbA1c ≥12%; Night-shift employment or other obligations that would preclude adherence to the intervention.