Vaccine Response in People With Kidney Failure on Dialysis
Studies how kidney failure affects immune protection after influenza vaccination in dialysis patients.
Plain-language title generated from the registry record
Registry title: Impact Of Kidney Failure On The Regulation Of Humoral Response To Vaccination
Key facts
- Where
- Milan, ItalySee the 3 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 70 years old?
Source: NCT06635525, who can take part
Where in Italy
- ASST Fatebenefratelli SaccoMilan, ItalyNot yet recruiting
- Asst Santi Paolo E CarloMilan, ItalyNot yet recruiting
- Fondazione IRCCS Cà Granda Ospedale Maggiore PoliclinicoMilan, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
- Trial code
- NCT06635525
- Record updated
- 30 March 2026
- Original description
The aim of this observational study is to determine if and how kidney failure affects the development of protective immune responses following vaccination in patients on chronic dialysis.Read full original descriptionShow less
Impact Of Kidney Failure On The Regulation Of Humoral Response To Vaccination
The aim of this observational study is to determine if and how kidney failure affects the development of protective immune responses following vaccination in patients on chronic dialysis.
Researchers will compare the effectiveness of the influenza vaccine in inducing protective antibodies between hemodialysis patients and subjects without chronic kidney disease.
Participants will:
* Be enrolled at the time of influenza vaccination * Visit the clinic at 7, 14, 30, 60, and 120 days after vaccination * Be asked to provide relevant clinical information and a blood sample at each visit
Inclusion: Age between 18 and 70 years; Patients undergoing thrice-weekly hemodialysis / peritoneal dialysis for at least 3 months OR healthy individuals without a history of renal insufficiency; Subjects eligible to receive a seasonal influenza vaccine; Signed informed consent for participation in the study.
Exclusion: Administration of immunosuppressive drugs in the two weeks prior to vaccination; Administration of another vaccine in the three weeks prior to enrollment (co-administration of other vaccines with those under study does not contraindicate participation); Systemic infection clinically resolved less than two weeks before enrollment; Recent influenza infection (clinically resolved less than 3 months ago).