Studies blood flow in pregnant women with obesity near term
Compares Doppler blood flow in arteries of obese and non-obese pregnant women at term.
Plain-language title generated from the registry record
Registry title: Obesity Doppler in Term Pregnancy
Key facts
- Where
- Asyut, EgyptSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 20 and 35 years old?
Source: NCT06644911, who can take part
Where in Egypt
- Woman's Health Hospital - Assiut universityAsyut, EgyptTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Assiut University
- Trial code
- NCT06644911
- Record updated
- 28 January 2025
- Original description
Maternal obesity is an epidemic in the developed world like Egypt. There are many pregnancy-associated complications including pre-eclampsia, gestational diabetes, and increased rates of septic wound after cesarean delivery. As a potential explanation of the etiology of complications due to maternal obesity, the role of endothelial dysfunction in the systemic and peripheral vasculatures has been hypothesized. It has been proposed that some adverse pregnancy outcomes in obese patients may be mediated by placental insufficiency. Utero-placental insufficiency is typically associated with fetal growth restriction and low birth weight.Read full original descriptionShow less
The Effect of Maternal Obesity on Umbilical and Uterine Artery Doppler in Term Pregnancy : a Cross-sectional Study
Maternal obesity is an epidemic in the developed world like Egypt. There are many pregnancy-associated complications including pre-eclampsia, gestational diabetes, and increased rates of septic wound after cesarean delivery. As a potential explanation of the etiology of complications due to maternal obesity, the role of endothelial dysfunction in the systemic and peripheral vasculatures has been hypothesized. It has been proposed that some adverse pregnancy outcomes in obese patients may be mediated by placental insufficiency. Utero-placental insufficiency is typically associated with fetal growth restriction and low birth weight.
Umbilical and uterine artery Doppler is widely accepted as a useful tool for monitoring high-risk pregnancies.
Normally, uterine artery vascular impedance gradually decreases until the late mid-trimester, owing to the establishment of a low-resistance placental circulation. Obesity has little impact on uterine vascular changes reflected by the early uterine artery PI. However, in the second trimester, extreme obesity appears to impair the normal continued drop in uterine vascular resistance. Many studies have examined the relationship between BMI and Doppler changes in high-risk pregnancies, but few have addressed these changes in low-risk pregnancies.
Inclusion: Singleton pregnancy; Gestational age ≥ 37 weeks; Absence of fetal structural abnormalities; Absence of maternal comorbidities and/or complications; Obese women (BMI ≥ 30 kg/m2) [11]; Normal weight (BMI 18.5-24.9) [11].
Exclusion: Women with antepartum hemorrhage; Diabetes mellitus; Placenta previa; Smokers and alcohol consumers; Preeclampsia; Women need urgent termination of pregnancy.