Studies blood flow in pregnant women with obesity near term
Compares Doppler blood flow in arteries of obese and non-obese pregnant women at term.
Plain-language title generated from the registry record
Registry title: Obesity Doppler in Term Pregnancy
Key facts
- Where
- Asyut, EgyptSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for pregnant women at term with one baby, who are either obese or of normal weight, and have no other health problems.
- Age
- 20 to 35 years
- Sex
- Women only
- Disease stage
- Single pregnancy at 37 weeks or more, with no structural problems in the baby and no other illness or complication in the mother.
- Biomarker or test result
- Body mass index (BMI) of 30 kg/m2 or more (obese), or 18.5-24.9 (normal weight).
Main reasons for not taking part
- Placenta previa
- Bleeding before birth (antepartum hemorrhage)
- Smoking or alcohol use
- Preeclampsia
- Diabetes mellitus
This trial only enrols pregnant participants. The registry sentence this rests on: Singleton pregnancy
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 20 and 35 years old?
Source: NCT06644911, who can take part
Where in Egypt
- Woman's Health Hospital - Assiut universityAsyut, EgyptContact: Mohammed K ALi, MDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Assiut University
- Trial code
- NCT06644911
- Record updated
- 28 January 2025
- Original description
Maternal obesity is an epidemic in the developed world like Egypt. There are many pregnancy-associated complications including pre-eclampsia, gestational diabetes, and increased rates of septic wound after cesarean delivery. As a potential explanation of the etiology of complications due to maternal obesity, the role of endothelial dysfunction in the systemic and peripheral vasculatures has been hypothesized. It has been proposed that some adverse pregnancy outcomes in obese patients may be mediated by placental insufficiency. Utero-placental insufficiency is typically associated with fetal growth restriction and low birth weight.Read full original descriptionShow less
The Effect of Maternal Obesity on Umbilical and Uterine Artery Doppler in Term Pregnancy : a Cross-sectional Study
Maternal obesity is an epidemic in the developed world like Egypt. There are many pregnancy-associated complications including pre-eclampsia, gestational diabetes, and increased rates of septic wound after cesarean delivery. As a potential explanation of the etiology of complications due to maternal obesity, the role of endothelial dysfunction in the systemic and peripheral vasculatures has been hypothesized. It has been proposed that some adverse pregnancy outcomes in obese patients may be mediated by placental insufficiency. Utero-placental insufficiency is typically associated with fetal growth restriction and low birth weight.
Umbilical and uterine artery Doppler is widely accepted as a useful tool for monitoring high-risk pregnancies.
Normally, uterine artery vascular impedance gradually decreases until the late mid-trimester, owing to the establishment of a low-resistance placental circulation. Obesity has little impact on uterine vascular changes reflected by the early uterine artery PI. However, in the second trimester, extreme obesity appears to impair the normal continued drop in uterine vascular resistance. Many studies have examined the relationship between BMI and Doppler changes in high-risk pregnancies, but few have addressed these changes in low-risk pregnancies.
Inclusion: Singleton pregnancy; Gestational age ≥ 37 weeks; Absence of fetal structural abnormalities; Absence of maternal comorbidities and/or complications; Obese women (BMI ≥ 30 kg/m2) [11]; Normal weight (BMI 18.5-24.9) [11].
Exclusion: Women with antepartum hemorrhage; Diabetes mellitus; Placenta previa; Smokers and alcohol consumers; Preeclampsia; Women need urgent termination of pregnancy.