NCT06646289Active, not recruitingPhase 2
A Follow-on Study for Second-Eye Treatment for Participants Previously Treated With Gene Therapy for X-Linked Retinitis Pigmentosa (XLRP)
An Open-label, Multicenter, Phase 2 Follow-on Study for Second Eye Treatment of Patients Previously Treated With a Recombinant Adeno-associated Virus Vector (AAV5 hRKp.RPGR) for Gene Therapy of Adults and Children With X-linked Retinitis Pigmentosa Owing to Defects in Retinitis Pigmentosa GTPase Regulator (RPGR)
Source: ClinicalTrials.gov · Last updated 25 Sept 2026
Brief summary (registry, in English)
The purpose of this study is to assess the safety and tolerability of subretinal delivery of Adeno-associated Virus Vector (AAV5 hRKp.RPGR) gene therapy in adults and children with X-linked retinitis pigmentosa.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 24 (actual)
- First submitted
- 16 Oct 2024
- Start date
- 10 Oct 2024
- Primary completion date
- 24 Oct 2030
- Lead sponsor
- MeiraGTx Ocular UK Ltd
- Diseases
- Retinitis pigmentosa
- NCT number
- NCT06646289
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 24
- From 10 Oct 2024 to the primary completion date, 24 Oct 2030
- 3 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- \- There are no specific exclusion criteria to enroll in this study
Who the study is looking for
- Have been treated with AAV5-hRKp.RPGR in study MGT009 and have completed or is currently enrolled in Study MGT010
- Must sign an informed consent form indicating that they understand the purpose and procedures of the study and is willing to participate in the study
- Willing to adhere to the protocol and long-term follow-up
Age in the registry: 5 years to - · Sex: Male · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Moorfields Eye Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| University of Michigan Kellogg Eye Center Coordinator of this site? Confirm its status | Ann Arbor | United States | Unknown status |
| Massachusetts Eye and Ear Infirmary Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.