Studies sleep quality in ICU patients with COPD on breathing machines
Compares sleep in COPD patients whose breathing-machine weaning test succeeds or fails.
Plain-language title generated from the registry record
Registry title: Study of Sleep Quality in the Intensive Care Unit and Association with Weaning from Invasive Ventilation in Patients with Chronic Obstructive Bronchopneumopathy.
Key facts
- Where
- Grenoble, FranceSee the site
Where in France
- Grenoble Alpes University HospitalGrenoble, FranceNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital, Grenoble
- Trial code
- NCT06653933
- Record updated
- 23 October 2024
- Original description
Patients admitted in ICU may require invasive mechanical ventilation, using a mechanical ventilator and an endotracheal tube.Read full original descriptionShow less
Study of Sleep Quality in the Intensive Care Unit and Association with Weaning from Invasive Ventilation in Patients with Chronic Obstructive Bronchopneumopathy.
Patients admitted in ICU may require invasive mechanical ventilation, using a mechanical ventilator and an endotracheal tube.
In ICU, a prolonged duration of invasive mechanical ventilation may be responsible for ventilator-induced lung injury, pulmonary infection, prolonged administration of sedation, neuromyopathy and prolonged length of stay. The goal of the ICU healthcare teams is therefore to reduce the duration of invasive mechanical ventilation as much as possible.
ICU patients have many sleep disturbances: sleep fragmentation, sleep stage changes, changes in sleep architecture. These sleep disturbances are due to sedation and analgesia, delirium, patient care activities, noise and altered day-night cycles.
Chronic obstructive pulmonary disease (COPD) is a common respiratory disease. COPD complicates the management of invasive mechanical ventilation, particularly weaning of this invasive mechanical ventilation and extubation (removal of the intubation tube).
To reduce the risk of reintubation, it is recommended that a weaning test is performed prior to extubation. The purpose of this test is to simulate the conditions of breathing without the help of a ventilator after extubation. If the weaning test is successful, the patient can theoretically be extubated.
There are several causes associated with extubation failure, but studies suggest that sleep deprivation or poor sleep quality in the nights before extubation is one of them. In addition, patients with COPD often have chronic sleep disturbances or induced by their stay in the ICU (asthenia, bed rest, anxiety, sedation, etc.).
The aim of our study will be to compare the sleep characteristics of COPD patients with a failed weaning test and those with a successful test. Our hypothesis is that patients with a failed weaning test will have more sleep disturbances in the period of 72 hours before the weaning test.
Inclusion: Patients diagnosed with COPD according to the GOLD criteria; Mechanical ventilation by endotracheal tube and mechanical ventilation for \> 24 hours; Withdrawal of treatment with continuous sedation and/or neuroleptics; Adequate recovery with Glasgow Coma Scale ≥ 8.
Exclusion: Patients with central nervous system damage or neuromuscular pathology; Pregnant or postpartum patients; Patients or their relatives who object to participating in the study.