Removing Visible Blood Clots Before Heart Stent Procedure in Heart Attack
Tests manual clot removal before stenting in people with a STEMI heart attack.
Plain-language title generated from the registry record
Registry title: Manual Thrombus Aspiration During PCI in STEMI With Angiographically Evident Thrombus
Key facts
- Where
- Changsha, ChinaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for people having a heart attack of the STEMI type, with a visible blood clot in the blocked heart artery. It tests removing the clot by hand before the stent procedure (PCI).
- Sex
- Men and women can join.
- Disease stage
- Confirmed ST-segment elevation heart attack (STEMI), with 24 hours or less from the first symptoms to arrival at the hospital. A clot seen on the heart artery scan (TIMI thrombus grade 2 or higher).
- Earlier treatment
- The clot must be seen before the guidewire crosses it or before any step that could change the clot size.
Main reasons for not taking part
- Cardiogenic shock (very low blood pressure with poor blood supply to the organs)
- Need for emergency heart bypass surgery
- A serious illness outside the heart and blood vessels, with expected survival of less than 6 months
- Written consent cannot be obtained from the person or a legal representative
Read by machine on 12 November 2026.
Where in China
- Department of Cardiology, The Second Xiangya Hospital of Central South UniversityChangsha, ChinaContact: Shenghua Zhou, MDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Shenghua Zhou
- Trial code
- NCT06654453
- Record updated
- 9 September 2026
- Original description
The goal of this clinical trial is to determine whether manually removing a visible blood clot before percutaneous coronary intervention (PCI) improves outcomes in patients with ST-segment elevation myocardial infarction (STEMI). About 3500 patients who present within 24 hours of symptom onset and have angiographically evident thrombus in the culprit coronary artery (TIMI thrombus grade 2 or higher) will be randomly assigned in a 1:1 ratio to manual thrombus aspiration followed by PCI or PCI alone.Read full original descriptionShow less
Percutaneous Coronary Intervention With or Without Manual Thrombus Aspiration in Patients With ST-Segment Elevation Myocardial Infarction and Angiographically Evident Thrombus
The goal of this clinical trial is to determine whether manually removing a visible blood clot before percutaneous coronary intervention (PCI) improves outcomes in patients with ST-segment elevation myocardial infarction (STEMI). About 3500 patients who present within 24 hours of symptom onset and have angiographically evident thrombus in the culprit coronary artery (TIMI thrombus grade 2 or higher) will be randomly assigned in a 1:1 ratio to manual thrombus aspiration followed by PCI or PCI alone.
The main question is whether adding manual thrombus aspiration reduces the first major adverse cardiac or cerebrovascular event within 30 days. This composite includes death from any cause, recurrent myocardial infarction, stroke, rehospitalization for heart failure, or clinically indicated target-vessel revascularization.
Researchers will also compare coronary and myocardial reperfusion after PCI, individual clinical events, stroke and other safety outcomes, and major adverse cardiac or cerebrovascular events through 6 and 12 months. Participants will receive their assigned PCI strategy and will be followed during the index hospitalization and at 30 days, 6 months, and 12 months.
Inclusion: Confirmed ST-segment elevation myocardial infarction with symptom onset-to-hospital arrival of 24 hours or less; Angiographically evident thrombus in the culprit vessel, defined as TIMI thrombus grade 2 or higher before guidewire crossing or any intervention that could alter thrombus burden; Written informed consent obtained from the participant or a legally authorized representative before randomization.
Exclusion: A serious noncardiovascular condition associated with an expected survival of less than 6 months; Cardiogenic shock, defined as persistent systolic blood pressure below 90 mmHg for at least 30 minutes or a need for vasopressor support to maintain systolic blood pressure of at least 90 mmHg, together with evidence of end-organ hypoperfusion; Requirement for emergency coronary artery bypass grafting; Inability to obtain written informed consent from the participant or a legally authorized representative.