Evaluation of Exercise Testing and Physical Activity in Children and Adolescents Living With Inherited Arrhythmias
Key facts
- Who runs it
- Royal Brompton & Harefield NHS Foundation Trust
- Where
- United Kingdom2 sites in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 55 people enrolled
- Started
- 18 Mar 2025
- Ended
- 31 May 2026
- Type of study
- Observational, 2 groups
- Treatments tested
- Exercise tolerance test
- Physical activity & heart rate monitoring
- Record updated
- 1 September 2026
Who can take part
- Age
- 6 years to 16 years
- Sex
- Women and men
- Healthy volunteers
- Can take part
The registry criteria, word for word
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Who can take part
- Affected cohort
- Male and female children
- Aged 6-16 years
- Diagnosed with long QT syndrome or catecholaminergic polymorphic ventricular tachycardia
- Treated with beta-blocker and/or sodium channel blockade
- Able to complete a treadmill ETT; Healthy cohort
- Male and female children
- Aged 6-16 years
- Siblings of affected children (gene negative)
- Undergoing IAS screening
- Able to complete a treadmill ETT
Who cannot take part
- Children aged less than 6 years
- Adults, 17 years of age and above
- Unable to run on an exercise treadmill due to physical limitations
- Individuals unable to speak or understand English, due to no translation service available
- Pregnancy
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
The goal of this observational study is to evaluate exercise testing and daily physical activity in children and adolescents who are diagnosed with an inherited arrhythmia.
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The main question it aims to answer is: Does maximum heart rate during controlled exercise tolerance testing accurately reflect maximum heart rate and peak exercise levels during free living daily physical activity in children and adolescents diagnosed with an inherited arrhythmia?
Participants will:
* Complete routine exercise tolerance testing * Record daily physical activity and exercise over two weeks, while wearing an activity and heart rate monitor and digit diary. * Complete a physical activity questionnaire at the end of two weeks.
The 2 groups in the trial
- Affected
Children diagnosed with Long QT Syndrome and Catecholaminergic Polymorphic Ventricular Tachycardia
Treatment: Exercise tolerance test and Physical activity & heart rate monitoring
- Unaffected
Healthy children (siblings of affected or those undergoing screening)
Treatment: Exercise tolerance test and Physical activity & heart rate monitoring
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Evaluation of Free-living Physical Activity and the Assessment Tools Used to Support Pharmacological Therapy Titration and Exercise Prescription in Children and Adolescents Diagnosed With Inherited Arrhythmias
- Record updated
- 1 September 2026