Taking people in United StatesPhase 3
Adding tivozanib to pembrolizumab after kidney cancer surgery
Tests adding tivozanib to pembrolizumab in adults with high-risk kidney cancer.
Plain-language title generated from the registry record
Registry title: Testing the Addition of the Anti-Cancer Drug Tivozanib to Immunotherapy (Pembrolizumab) After Surgery to Remove All Known Sites of Kidney Cancer
Key facts
- Where
- Albuquerque, Allentown, Altoona, Amarillo, Ames, Anaconda, Appleton, Asheville, Ashland, Atlanta, Auburn, Aurora, Avon, Ballwin, Baltimore, Barrington, Basking Ridge, Battle Creek, Baytown, Beachwood, Beaver, Beavercreek, Bemidji, Berlin Corners, Bethlehem, Bettendorf, Beverly, Beverly Hills, Billings, Bismarck, Bloomington, Boiling Springs, Boise, Boone, Boston, Bozeman, Brainerd, Brewer, Bridgeport, Brighton, Buffalo, Burlington, Burnsville, Butler, Camillus, Canton, Cape Girardeau, Carmel, Carterville, Carthage, Cary, Cedar Rapids, Centerville, Chapel Hill, Charleston, Chelsea, Cherry Hill, Chicago, City of Saint Peters, Cleveland, Clyde, Coeur d'Alene, Collierville, Colorado Springs, Columbus, Commack, Coon Rapids, Creve Coeur, Crystal Lake, Cudahy, Cumberland, Cypress, Dallas, Danville, Dayton, Decatur, Deer River, DeKalb, Denver, Derby, Dickson City, Dixon, Downers Grove, Duarte, Duluth, Durham, Easley, East Stroudsburg, East Syracuse, Edina, Effingham, Elgin, Elmhurst, Erie, Escanaba, Eureka, Fairfield, Fargo, Farmington, Flint, Fort Collins, Fort Dodge, Fort Worth, Foxborough, Franklin, Fruitland, Gaffney, Gainesville, Galesburg, Geneva, Georgetown, Germantown, Glastonbury, Glen Burnie, Glens Falls, Glenview, Gloucester, Grafton, Grand Rapids, Grayslake, Great Falls, Greeley, Green Bay, Greensburg, Greenville, Greenwich, Greer, Grenada, Guilford, Hackensack, Hamilton, Harrisburg, Harrison, Hartford, Hazel Crest, Hazleton, Hendersonville, Hibbing, Highlands Ranch, Houston, Indiana, Indianapolis, Iowa City, Irvine, Jackson, Jefferson, Johns Creek, Johnstown, Jonesboro, Kalamazoo, Kalispell, Kenosha, Kettering, Kewanee, La Crosse, La Jolla, Lake Forest, Lake Success, Lancaster, Lansing, Lawton, Lebanon, Lewisburg, Lexington, Libertyville, Little Rock, Livonia, Lone Tree, Long Branch, Los Angeles, Louisville, Loveland, Macomb, Madison, Manchester, Maplewood, Marinette, Marshalltown, Martinsburg, Mattoon, Mechanicsburg, Mechanicsville, Memphis, Menomonee Falls, Mentor, Meriden, Meridian, Methuen, Miami, Middletown, Midlothian, Milford, Millville, Milwaukee, Minneapolis, Missoula, Modesto, Moline, Monroeville, Montvale, Morgantown, Morristown, Mount Kisco, Mukwonago, Muskegon, Nampa, Naperville, Nashville, Nassau Bay, New Albany, New Britain, New Brunswick, New Haven, New Orleans, New Richmond, New York, Newark, Newberg, Newport Beach, Niles, North Haven, Norton Shores, O'Fallon, Oak Brook, Oak Creek, Oak Lawn, Oconomowoc, Oconto Falls, Oklahoma City, Orange, Oregon City, Orland Park, Oshkosh, Ottawa, Oxford, Palo Alto, Palos Heights, Park Ridge, Parkersburg, Peabody, Pekin, Peoria, Peru, Philadelphia, Phoenix, Pinehurst, Pittsburgh, Plainfield, Pontiac, Portland, Post Falls, Princeton, Racine, Raleigh, Reed City, Rehoboth Beach, Richardson, Richmond, Robbinsdale, Rockford, Roseville, Sacramento, Saint Cloud, Saint Johnsbury, Saint Joseph, Saint Louis Park, Saint Paul, Sainte Genevieve, San Diego, San Francisco, San Mateo, Sandpoint, Sandstone, Santa Cruz, Scranton, Seneca, Sewell, Shakopee, Sheboygan, Shiloh, Sioux Falls, Sleepy Hollow, Somerville, South Hill, South Weymouth, Southhaven, Spartanburg, Springfield, St Louis, Stamford, Sturgeon Bay, Sugar Land, Sullivan, Summit, Sunnyvale, Temple, The Bronx, The Woodlands, Torrance, Torrington, Traverse City, Troy, Trumbull, Tucson, Two Rivers, Union, Uniondale, Uniontown, Upland, Urbana, Vallejo, Virginia, Warrenville, Washington, Washington D.C., Waterbury, Waterford, Waukesha, Wauwatosa, Weaverville, West Allis, West Bend, Westerly, Wilkes-Barre, Williamsport, Woodbury, Wyoming, Yorkville, and Ypsilanti, United StatesSee the 429 sites
- Phase
- Phase 3
Where in United States
- University of New Mexico Cancer CenterAlbuquerque, United StatesTaking people
- Lehigh Valley Hospital-Cedar CrestAllentown, United StatesTaking people
- UPMC AltoonaAltoona, United StatesTaking people
- The Don and Sybil Harrington Cancer CenterAmarillo, United StatesTaking people
- Mary Greeley Medical CenterAmes, United StatesTaking people
- McFarland Clinic - AmesAmes, United StatesTaking people
- Community Hospital of AnacondaAnaconda, United StatesTaking people
- ThedaCare Regional Cancer CenterAppleton, United StatesTaking people
- AdventHealth Infusion Center AshevilleAsheville, United StatesTaking people
- Duluth Clinic AshlandAshland, United StatesTaking people
- Emory Saint Joseph's HospitalAtlanta, United StatesTaking people
- Emory University Hospital MidtownAtlanta, United StatesTaking people
- Emory University Hospital/Winship Cancer InstituteAtlanta, United StatesTaking people
- Grady Health SystemAtlanta, United StatesTaking people
- Sutter Auburn Faith HospitalAuburn, United StatesTaking people
- Advocate Outpatient Center - AuroraAurora, United StatesTaking people
- UCHealth University of Colorado HospitalAurora, United StatesTaking people
- Rush-Copley Medical CenterAurora, United StatesNo longer taking part
- Hartford HealthCare - AvonAvon, United StatesTaking people
- UH Seidman Cancer Center at UH Avon Health CenterAvon, United StatesTaking people
- IU Health West HospitalAvon, United StatesNo longer taking part
- Mercy Oncology and Hematology - Clayton-ClarksonBallwin, United StatesTaking people
- University of Maryland/Greenebaum Cancer CenterBaltimore, United StatesTaking people
- Advocate Good Shepherd HospitalBarrington, United StatesTaking people
- Memorial Sloan Kettering Basking RidgeBasking Ridge, United StatesTaking people
- Bronson Battle CreekBattle Creek, United StatesTaking people
- Houston Methodist San Jacinto HospitalBaytown, United StatesTaking people
- UHHS-Chagrin Highlands Medical CenterBeachwood, United StatesTaking people
- UPMC-Heritage Valley Health System BeaverBeaver, United StatesTaking people
- Indu and Raj Soin Medical CenterBeavercreek, United StatesNo longer taking part
- Sanford Joe Lueken Cancer CenterBemidji, United StatesTaking people
- Central Vermont Medical Center/National Life Cancer TreatmentBerlin Corners, United StatesTaking people
- Lehigh Valley Hospital - MuhlenbergBethlehem, United StatesTaking people
- University of Iowa Healthcare Cancer Services Quad CitiesBettendorf, United StatesTaking people
- Beverly HospitalBeverly, United StatesTaking people
- Tower Cancer Research FoundationBeverly Hills, United StatesTaking people
- Billings Clinic Cancer CenterBillings, United StatesTaking people
- Sanford Bismarck Medical CenterBismarck, United StatesTaking people
- Illinois CancerCare-BloomingtonBloomington, United StatesTaking people
- Prisma Health Cancer Institute - SpartanburgBoiling Springs, United StatesTaking people
- Saint Luke's Cancer Institute - BoiseBoise, United StatesTaking people
- McFarland Clinic - BooneBoone, United StatesNo longer taking part
- Dana-Farber Cancer InstituteBoston, United StatesTaking people
- Tufts Medical CenterBoston, United StatesTaking people
- Bozeman Health Deaconess HospitalBozeman, United StatesTaking people
- Essentia Health Saint Joseph's Medical CenterBrainerd, United StatesTaking people
- Lafayette Family Cancer Center-EMMCBrewer, United StatesTaking people
- Hartford HealthCare - Saint Vincent's Medical CenterBridgeport, United StatesTaking people
- United Hospital CenterBridgeport, United StatesTaking people
- Trinity Health IHA Medical Group Hematology Oncology - BrightonBrighton, United StatesTaking people
- Roswell Park Cancer InstituteBuffalo, United StatesTaking people
- Aurora Cancer Care-Southern Lakes VLCCBurlington, United StatesTaking people
- Lahey ClinicBurlington, United StatesTaking people
- University of Vermont and State Agricultural CollegeBurlington, United StatesTaking people
- University of Vermont Medical CenterBurlington, United StatesTaking people
- Minnesota Oncology - BurnsvilleBurnsville, United StatesTaking people
- UPMC Hillman Cancer Center at Butler Health SystemButler, United StatesTaking people
- Hematology Oncology Associates of CNY at CamillusCamillus, United StatesTaking people
- Aultman Health FoundationCanton, United StatesTaking people
- Illinois CancerCare-CantonCanton, United StatesTaking people
- Trinity Health IHA Medical Group Hematology Oncology - CantonCanton, United StatesTaking people
- Saint Francis Medical CenterCape Girardeau, United StatesTaking people
- IU Health North HospitalCarmel, United StatesNo longer taking part
- SIH Cancer InstituteCarterville, United StatesTaking people
- Illinois CancerCare-CarthageCarthage, United StatesTaking people
- Duke Cancer Center CaryCary, United StatesTaking people
- Waverly Hematology OncologyCary, United StatesTaking people
- Mercy HospitalCedar Rapids, United StatesTaking people
- Oncology Associates at Mercy Medical CenterCedar Rapids, United StatesTaking people
- Miami Valley Hospital SouthCenterville, United StatesTaking people
- UNC Lineberger Comprehensive Cancer CenterChapel Hill, United StatesTaking people
- Medical University of South CarolinaCharleston, United StatesTaking people
- Vandalia Health/CAMC Institute for Academic MedicineCharleston, United StatesTaking people
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea HospitalChelsea, United StatesTaking people
- Jefferson Cherry Hill HospitalCherry Hill, United StatesTaking people
- Advocate Illinois Masonic Medical CenterChicago, United StatesTaking people
- Northwestern UniversityChicago, United StatesTaking people
- Rush MD Anderson Cancer CenterChicago, United StatesTaking people
- University of IllinoisChicago, United StatesTaking people
- Siteman Cancer Center at Saint Peters HospitalCity of Saint Peters, United StatesTaking people
- Case Western Reserve UniversityCleveland, United StatesTaking people
- AdventHealth Infusion Center HaywoodClyde, United StatesTaking people
- Kootenai Health - Coeur d'AleneCoeur d'Alene, United StatesTaking people
- Baptist Memorial Hospital and Cancer Center-ColliervilleCollierville, United StatesTaking people
- Memorial Hospital NorthColorado Springs, United StatesTaking people
- UCHealth Memorial Hospital CentralColorado Springs, United StatesTaking people
- Baptist Memorial Hospital and Cancer Center-Golden TriangleColumbus, United StatesTaking people
- Ohio State University Comprehensive Cancer CenterColumbus, United StatesTaking people
- Memorial Sloan Kettering CommackCommack, United StatesTaking people
- Mercy HospitalCoon Rapids, United StatesTaking people
- Siteman Cancer Center at West County HospitalCreve Coeur, United StatesTaking people
- AMG Crystal Lake - OncologyCrystal Lake, United StatesTaking people
- Aurora Saint Luke's South ShoreCudahy, United StatesTaking people
- UPMC Western MarylandCumberland, United StatesTaking people
- Houston Methodist Cypress HospitalCypress, United StatesTaking people
- Parkland Memorial HospitalDallas, United StatesTaking people
- UT Southwestern Simmons Cancer Center - RedBirdDallas, United StatesTaking people
- UT Southwestern/Simmons Cancer Center-DallasDallas, United StatesTaking people
- Carle at The RiverfrontDanville, United StatesTaking people
- Geisinger Medical CenterDanville, United StatesTaking people
- Miami Valley HospitalDayton, United StatesTaking people
- Miami Valley Hospital NorthDayton, United StatesTaking people
- Cancer Care Specialists of Illinois - DecaturDecatur, United StatesTaking people
- Decatur Memorial HospitalDecatur, United StatesTaking people
- Essentia Health - Deer River ClinicDeer River, United StatesTaking people
- Northwestern Medicine Cancer Center KishwaukeeDeKalb, United StatesTaking people
- UCHealth - Cherry CreekDenver, United StatesTaking people
- Smilow Cancer Hospital-Derby Care CenterDerby, United StatesTaking people
- Geisinger Cancer Center Dickson CityDickson City, United StatesTaking people
- Illinois CancerCare-DixonDixon, United StatesTaking people
- Advocate Good Samaritan HospitalDowners Grove, United StatesTaking people
- City of Hope Comprehensive Cancer CenterDuarte, United StatesTaking people
- Essentia Health Cancer CenterDuluth, United StatesTaking people
- Duke Cancer Center SouthpointDurham, United StatesTaking people
- Duke University Medical CenterDurham, United StatesNo longer taking part
- Prisma Health Cancer Institute - EasleyEasley, United StatesTaking people
- Pocono Medical CenterEast Stroudsburg, United StatesTaking people
- Hematology Oncology Associates of Central New York-East SyracuseEast Syracuse, United StatesTaking people
- Fairview Southdale HospitalEdina, United StatesTaking people
- Minnesota Oncology - EdinaEdina, United StatesTaking people
- Carle Physician Group-EffinghamEffingham, United StatesTaking people
- Crossroads Cancer CenterEffingham, United StatesTaking people
- Advocate Sherman HospitalElgin, United StatesTaking people
- Elmhurst Memorial HospitalElmhurst, United StatesTaking people
- UPMC Hillman Cancer Center ErieErie, United StatesTaking people
- OSF Saint Francis Hospital and Medical GroupEscanaba, United StatesTaking people
- Illinois CancerCare-EurekaEureka, United StatesTaking people
- Hartford Healthcare - FairfieldFairfield, United StatesTaking people
- Smilow Cancer Hospital Care Center-FairfieldFairfield, United StatesTaking people
- Essentia Health Cancer Center-South University ClinicFargo, United StatesTaking people
- Sanford Broadway Medical CenterFargo, United StatesTaking people
- Sanford Roger Maris Cancer CenterFargo, United StatesTaking people
- Parkland Health Center - FarmingtonFarmington, United StatesTaking people
- Cancer Hematology Centers - FlintFlint, United StatesTaking people
- Genesys Hurley Cancer InstituteFlint, United StatesTaking people
- Genesee Hematology Oncology PCFlint, United StatesNo longer taking part
- Cancer Care and Hematology-Fort CollinsFort Collins, United StatesTaking people
- Poudre Valley HospitalFort Collins, United StatesTaking people
- McFarland Clinic - Trinity Cancer CenterFort Dodge, United StatesTaking people
- UT Southwestern/Simmons Cancer Center-Fort WorthFort Worth, United StatesTaking people
- Dana-Farber Cancer Institute at FoxboroughFoxborough, United StatesTaking people
- Atrium Medical Center-Middletown Regional HospitalFranklin, United StatesTaking people
- Saint Luke's Cancer Institute - FruitlandFruitland, United StatesTaking people
- Gibbs Cancer Center-GaffneyGaffney, United StatesTaking people
- UF Health Cancer Institute - GainesvilleGainesville, United StatesTaking people
- Illinois CancerCare-GalesburgGalesburg, United StatesTaking people
- Northwestern Medicine Cancer Center DelnorGeneva, United StatesTaking people
- Tidelands Georgetown Memorial HospitalGeorgetown, United StatesTaking people
- Aurora Health Care Germantown Health CenterGermantown, United StatesTaking people
- Smilow Cancer Hospital Care Center at GlastonburyGlastonbury, United StatesNo longer taking part
- UM Baltimore Washington Medical Center/Tate Cancer CenterGlen Burnie, United StatesTaking people
- Glens Falls HospitalGlens Falls, United StatesTaking people
- Northwestern Medicine Glenview Outpatient CenterGlenview, United StatesTaking people
- Addison Gilbert HospitalGloucester, United StatesTaking people
- Aurora Cancer Care-GraftonGrafton, United StatesTaking people
- Corewell Health Grand Rapids Hospitals - Butterworth HospitalGrand Rapids, United StatesTaking people
- Trinity Health Grand Rapids HospitalGrand Rapids, United StatesNo longer taking part
- Northwestern Medicine Grayslake Outpatient CenterGrayslake, United StatesTaking people
- Benefis Sletten Cancer InstituteGreat Falls, United StatesTaking people
- UCHealth Greeley HospitalGreeley, United StatesTaking people
- Aurora BayCare Medical CenterGreen Bay, United StatesTaking people
- Saint Vincent Hospital Cancer Center at Saint Mary'sGreen Bay, United StatesTaking people
- Saint Vincent Hospital Cancer Center Green BayGreen Bay, United StatesTaking people
- UPMC Cancer Centers - Arnold Palmer PavilionGreensburg, United StatesTaking people
- Miami Valley Cancer Care and InfusionGreenville, United StatesTaking people
- Prisma Health Cancer Institute - ButternutGreenville, United StatesTaking people
- Prisma Health Cancer Institute - EastsideGreenville, United StatesTaking people
- Prisma Health Cancer Institute - FarisGreenville, United StatesTaking people
- Smilow Cancer Hospital Care Center at GreenwichGreenwich, United StatesTaking people
- Gibbs Cancer Center-PelhamGreer, United StatesTaking people
- Prisma Health Cancer Institute - GreerGreer, United StatesTaking people
- Baptist Cancer Center-GrenadaGrenada, United StatesTaking people
- Smilow Cancer Hospital Care Center - GuilfordGuilford, United StatesTaking people
- Hackensack University Medical CenterHackensack, United StatesTaking people
- The Cancer Institute of New Jersey HamiltonHamilton, United StatesNo longer taking part
- UPMC Pinnacle Cancer Center/Community Osteopathic CampusHarrisburg, United StatesTaking people
- Memorial Sloan Kettering WestchesterHarrison, United StatesTaking people
- Hartford HospitalHartford, United StatesTaking people
- Smilow Cancer Hospital Care Center at Saint FrancisHartford, United StatesNo longer taking part
- Advocate South Suburban HospitalHazel Crest, United StatesTaking people
- Geisinger Medical Center-Cancer Center HazletonHazleton, United StatesTaking people
- Lehigh Valley Hospital-HazletonHazleton, United StatesTaking people
- AdventHealth HendersonvilleHendersonville, United StatesTaking people
- Essentia Health Hibbing ClinicHibbing, United StatesTaking people
- UCHealth Highlands Ranch HospitalHighlands Ranch, United StatesTaking people
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer CenterHouston, United StatesTaking people
- Ben Taub General HospitalHouston, United StatesTaking people
- Houston Methodist HospitalHouston, United StatesTaking people
- Houston Methodist West HospitalHouston, United StatesTaking people
- Methodist Willowbrook HospitalHouston, United StatesTaking people
- IRMC Cancer CenterIndiana, United StatesTaking people
- Sidney and Lois Eskenazi HospitalIndianapolis, United StatesTaking people
- Indiana University/Melvin and Bren Simon Cancer CenterIndianapolis, United StatesNo longer taking part
- University of Iowa/Holden Comprehensive Cancer CenterIowa City, United StatesTaking people
- City of Hope at Irvine LennarIrvine, United StatesTaking people
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory CareIrvine, United StatesTaking people
- University of Mississippi Medical CenterJackson, United StatesTaking people
- McFarland Clinic - JeffersonJefferson, United StatesNo longer taking part
- Emory Johns Creek HospitalJohns Creek, United StatesTaking people
- UPMC-Johnstown/John P. Murtha Regional Cancer CenterJohnstown, United StatesTaking people
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - JonesboroJonesboro, United StatesTaking people
- Bronson Methodist HospitalKalamazoo, United StatesTaking people
- West Michigan Cancer CenterKalamazoo, United StatesTaking people
- Logan Health Medical CenterKalispell, United StatesTaking people
- Aurora Cancer Care-Kenosha SouthKenosha, United StatesTaking people
- Kettering Medical CenterKettering, United StatesTaking people
- Illinois CancerCare-Kewanee ClinicKewanee, United StatesTaking people
- Gundersen Lutheran Medical CenterLa Crosse, United StatesTaking people
- UC San Diego Moores Cancer CenterLa Jolla, United StatesTaking people
- Northwestern Medicine Lake Forest HospitalLake Forest, United StatesTaking people
- Northwell Health/Center for Advanced MedicineLake Success, United StatesTaking people
- City of Hope Antelope ValleyLancaster, United StatesTaking people
- University of Michigan Health - Sparrow LansingLansing, United StatesTaking people
- Cancer Centers of Southwest Oklahoma ResearchLawton, United StatesTaking people
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer CenterLebanon, United StatesTaking people
- Geisinger Medical Oncology-LewisburgLewisburg, United StatesTaking people
- University of Kentucky/Markey Cancer CenterLexington, United StatesTaking people
- AMG Libertyville - OncologyLibertyville, United StatesTaking people
- Condell Memorial HospitalLibertyville, United StatesTaking people
- University of Arkansas for Medical SciencesLittle Rock, United StatesTaking people
- Trinity Health Saint Mary Mercy Livonia HospitalLivonia, United StatesTaking people
- UCHealth Lone Tree Health CenterLone Tree, United StatesTaking people
- Monmouth Medical CenterLong Branch, United StatesTaking people
- Cedars-Sinai Medical CenterLos Angeles, United StatesTaking people
- Los Angeles General Medical CenterLos Angeles, United StatesTaking people
- UCLA / Jonsson Comprehensive Cancer CenterLos Angeles, United StatesTaking people
- USC / Norris Comprehensive Cancer CenterLos Angeles, United StatesTaking people
- Baptist Health LouisvilleLouisville, United StatesTaking people
- The James Graham Brown Cancer Center at University of LouisvilleLouisville, United StatesTaking people
- UofL Health Medical Center NortheastLouisville, United StatesTaking people
- Medical Center of the RockiesLoveland, United StatesTaking people
- Illinois CancerCare-MacombMacomb, United StatesTaking people
- University of Wisconsin Carbone Cancer Center - Eastpark Medical CenterMadison, United StatesTaking people
- University of Wisconsin Carbone Cancer Center - University HospitalMadison, United StatesTaking people
- Hartford HealthCare - ManchesterManchester, United StatesTaking people
- Minnesota Oncology Hematology PA-MaplewoodMaplewood, United StatesTaking people
- Aurora Bay Area Medical Group-MarinetteMarinette, United StatesTaking people
- McFarland Clinic - MarshalltownMarshalltown, United StatesTaking people
- WVUH-Berkely Medical CenterMartinsburg, United StatesTaking people
- Carle Physician Group-Mattoon/CharlestonMattoon, United StatesTaking people
- UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer PavilionMechanicsburg, United StatesTaking people
- Bon Secours Memorial Regional Medical CenterMechanicsville, United StatesTaking people
- Baptist Memorial Hospital and Cancer Center-MemphisMemphis, United StatesTaking people
- Froedtert Menomonee Falls HospitalMenomonee Falls, United StatesTaking people
- UH Seidman Cancer Center at Lake Health Mentor CampusMentor, United StatesTaking people
- Midstate Medical CenterMeriden, United StatesTaking people
- Saint Luke's Cancer Institute - MeridianMeridian, United StatesTaking people
- Dana Farber-Merrimack ValleyMethuen, United StatesTaking people
- Miami Cancer InstituteMiami, United StatesTaking people
- Memorial Sloan Kettering MonmouthMiddletown, United StatesTaking people
- Bon Secours Saint Francis Medical CenterMidlothian, United StatesTaking people
- Dana-Farber/Brigham and Women's Cancer Center at Milford RegionalMilford, United StatesTaking people
- Beebe South Coastal Health CampusMillville, United StatesTaking people
- Aurora Cancer Care-MilwaukeeMilwaukee, United StatesTaking people
- Aurora Saint Luke's Medical CenterMilwaukee, United StatesTaking people
- Aurora Sinai Medical CenterMilwaukee, United StatesTaking people
- Medical College of WisconsinMilwaukee, United StatesTaking people
- Abbott-Northwestern HospitalMinneapolis, United StatesTaking people
- Hennepin County Medical CenterMinneapolis, United StatesTaking people
- Minneapolis VA Medical CenterMinneapolis, United StatesTaking people
- Community Medical CenterMissoula, United StatesTaking people
- Memorial Medical CenterModesto, United StatesTaking people
- Trinity Medical CenterMoline, United StatesTaking people
- UPMC Hillman Cancer Center - MonroevilleMonroeville, United StatesTaking people
- Memorial Sloan Kettering BergenMontvale, United StatesTaking people
- West Virginia University HealthcareMorgantown, United StatesTaking people
- Morristown Medical CenterMorristown, United StatesNo longer taking part
- Northern Westchester HospitalMount Kisco, United StatesTaking people
- ProHealth D N Greenwald CenterMukwonago, United StatesTaking people
- Trinity Health Muskegon HospitalMuskegon, United StatesNo longer taking part
- Saint Luke's Cancer Institute - NampaNampa, United StatesTaking people
- Edward Hospital/Cancer CenterNaperville, United StatesTaking people
- Vanderbilt University/Ingram Cancer CenterNashville, United StatesTaking people
- Houston Methodist Saint John HospitalNassau Bay, United StatesTaking people
- Baptist Memorial Hospital and Cancer Center-Union CountyNew Albany, United StatesTaking people
- The Hospital of Central ConnecticutNew Britain, United StatesTaking people
- Rutgers Cancer Institute of New JerseyNew Brunswick, United StatesTaking people
- Yale UniversityNew Haven, United StatesTaking people
- Ochsner Medical Center JeffersonNew Orleans, United StatesTaking people
- Cancer Center of Western WisconsinNew Richmond, United StatesTaking people
- Lenox Hill HospitalNew York, United StatesTaking people
- Manhattan Eye Ear and Throat HospitalNew York, United StatesTaking people
- Memorial Sloan-Kettering Cancer CenterNew York, United StatesTaking people
- Mount Sinai ChelseaNew York, United StatesTaking people
- Mount Sinai HospitalNew York, United StatesTaking people
- Helen F Graham Cancer CenterNewark, United StatesTaking people
- Medical Oncology Hematology Consultants PANewark, United StatesTaking people
- Rutgers New Jersey Medical SchoolNewark, United StatesTaking people
- Providence Newberg Medical CenterNewberg, United StatesTaking people
- USC Norris Oncology/Hematology-Newport BeachNewport Beach, United StatesTaking people
- Corewell Health Lakeland Hospitals - Niles HospitalNiles, United StatesTaking people
- Yale-New Haven Hospital North Haven Medical CenterNorth Haven, United StatesNo longer taking part
- Cancer and Hematology Centers of Western Michigan - Norton ShoresNorton Shores, United StatesNo longer taking part
- Cancer Care Center of O'FallonO'Fallon, United StatesTaking people
- Northwestern Medicine Oak BrookOak Brook, United StatesTaking people
- Drexel Town Square Health CenterOak Creek, United StatesTaking people
- Advocate Christ Medical CenterOak Lawn, United StatesTaking people
- Advocate Outpatient Center - Oak LawnOak Lawn, United StatesTaking people
- ProHealth Oconomowoc Memorial HospitalOconomowoc, United StatesTaking people
- Saint Vincent Hospital Cancer Center at Oconto FallsOconto Falls, United StatesTaking people
- University of Oklahoma Health Sciences CenterOklahoma City, United StatesTaking people
- UC Irvine Health- Chao Family Comprehensive Cancer CenterOrange, United StatesTaking people
- Providence Willamette Falls Medical CenterOregon City, United StatesTaking people
- Northwestern Medicine Orland ParkOrland Park, United StatesTaking people
- Vince Lombardi Cancer Clinic - OshkoshOshkosh, United StatesTaking people
- Illinois CancerCare-Ottawa ClinicOttawa, United StatesTaking people
- Baptist Memorial Hospital and Cancer Center-OxfordOxford, United StatesTaking people
- Palo Alto Medical Foundation Health CarePalo Alto, United StatesTaking people
- Advocate High Tech Medical ParkPalos Heights, United StatesTaking people
- Advocate Lutheran General HospitalPark Ridge, United StatesTaking people
- Camden Clark Medical CenterParkersburg, United StatesTaking people
- Lahey Clinic PeabodyPeabody, United StatesTaking people
- Illinois CancerCare-PekinPekin, United StatesTaking people
- Illinois CancerCare-PeoriaPeoria, United StatesTaking people
- Illinois CancerCare-PeruPeru, United StatesTaking people
- Jefferson Torresdale HospitalPhiladelphia, United StatesTaking people
- Thomas Jefferson University HospitalPhiladelphia, United StatesTaking people
- Cancer Center at Saint Joseph'sPhoenix, United StatesNo longer taking part
- FirstHealth of the Carolinas-Moore Regional HospitalPinehurst, United StatesTaking people
- UPMC Hillman Cancer CenterPittsburgh, United StatesTaking people
- UPMC-Passavant HospitalPittsburgh, United StatesTaking people
- UPMC-Saint Clair Hospital Cancer CenterPittsburgh, United StatesTaking people
- Edward Hospital/Cancer Center?PlainfieldPlainfield, United StatesTaking people
- Trinity Health Saint Joseph Mercy Oakland HospitalPontiac, United StatesTaking people
- Oregon Health and Science UniversityPortland, United StatesTaking people
- Providence Portland Medical CenterPortland, United StatesTaking people
- Providence Saint Vincent Medical CenterPortland, United StatesTaking people
- Kootenai Clinic Cancer Services - Post FallsPost Falls, United StatesTaking people
- Illinois CancerCare-PrincetonPrinceton, United StatesTaking people
- Aurora Cancer Care-RacineRacine, United StatesTaking people
- Duke Cancer Center RaleighRaleigh, United StatesTaking people
- Corewell Health Reed City HospitalReed City, United StatesTaking people
- Beebe Health CampusRehoboth Beach, United StatesTaking people
- UT Southwestern Clinical Center at Richardson/PlanoRichardson, United StatesTaking people
- Bon Secours Richmond Community HospitalRichmond, United StatesTaking people
- Bon Secours Saint Mary's HospitalRichmond, United StatesTaking people
- VCU Massey Cancer Center at Stony PointRichmond, United StatesTaking people
- VCU Massey Comprehensive Cancer CenterRichmond, United StatesTaking people
- Virginia Cancer InstituteRichmond, United StatesTaking people
- North Memorial Medical Health CenterRobbinsdale, United StatesTaking people
- UW Health Carbone Cancer Center RockfordRockford, United StatesTaking people
- Sutter Roseville Medical CenterRoseville, United StatesTaking people
- Sutter Medical Center SacramentoSacramento, United StatesTaking people
- University of California Davis Comprehensive Cancer CenterSacramento, United StatesTaking people
- Coborn Cancer Center at Saint Cloud HospitalSaint Cloud, United StatesTaking people
- Dartmouth Cancer Center - NorthSaint Johnsbury, United StatesTaking people
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer CenterSaint Joseph, United StatesTaking people
- Corewell Health Lakeland Hospitals - Saint Joseph HospitalSaint Joseph, United StatesTaking people
- Park Nicollet Clinic - Saint Louis ParkSaint Louis Park, United StatesTaking people
- Regions HospitalSaint Paul, United StatesTaking people
- United HospitalSaint Paul, United StatesTaking people
- Sainte Genevieve County Memorial HospitalSainte Genevieve, United StatesTaking people
- UC San Diego Medical Center - HillcrestSan Diego, United StatesTaking people
- California Pacific Medical Center-Pacific CampusSan Francisco, United StatesTaking people
- Mills Health CenterSan Mateo, United StatesTaking people
- Kootenai Clinic Cancer Services - SandpointSandpoint, United StatesTaking people
- Essentia Health SandstoneSandstone, United StatesTaking people
- Palo Alto Medical Foundation-Santa CruzSanta Cruz, United StatesTaking people
- Community Medical CenterScranton, United StatesTaking people
- Prisma Health Cancer Institute - SenecaSeneca, United StatesTaking people
- Sidney Kimmel Cancer Center Washington TownshipSewell, United StatesTaking people
- Saint Francis Regional Medical CenterShakopee, United StatesTaking people
- Saint Vincent Hospital Cancer Center at SheboyganSheboygan, United StatesTaking people
- Sheboygan Physicians GroupSheboygan, United StatesTaking people
- Vince Lombardi Cancer Clinic-SheboyganSheboygan, United StatesTaking people
- Memorial Hospital EastShiloh, United StatesTaking people
- Sanford Cancer Center Oncology ClinicSioux Falls, United StatesTaking people
- Sanford USD Medical Center - Sioux FallsSioux Falls, United StatesTaking people
- Phelps Memorial Hospital CenterSleepy Hollow, United StatesTaking people
- Robert Wood Johnson University Hospital SomersetSomerville, United StatesTaking people
- VCU Community Memorial Health CenterSouth Hill, United StatesTaking people
- Dana-Farber/Brigham and Women's Cancer Center at South ShoreSouth Weymouth, United StatesTaking people
- Baptist Memorial Hospital and Cancer Center-DesotoSouthhaven, United StatesTaking people
- Spartanburg Medical CenterSpartanburg, United StatesTaking people
- Southern Illinois University School of MedicineSpringfield, United StatesTaking people
- Springfield ClinicSpringfield, United StatesTaking people
- Springfield Memorial HospitalSpringfield, United StatesTaking people
- Mercy Hospital Saint LouisSt Louis, United StatesTaking people
- Mercy Hospital SouthSt Louis, United StatesTaking people
- Missouri Baptist Medical CenterSt Louis, United StatesTaking people
- Siteman Cancer Center at Christian HospitalSt Louis, United StatesTaking people
- Siteman Cancer Center-South CountySt Louis, United StatesTaking people
- Washington University School of MedicineSt Louis, United StatesTaking people
- Smilow Cancer Hospital Care Center at Long RidgeStamford, United StatesTaking people
- Stamford Hospital/Bennett Cancer CenterStamford, United StatesTaking people
- Saint Vincent Hospital Cancer Center at Sturgeon BaySturgeon Bay, United StatesTaking people
- Houston Methodist Sugar Land HospitalSugar Land, United StatesTaking people
- Missouri Baptist Sullivan HospitalSullivan, United StatesTaking people
- Aurora Medical Center in SummitSummit, United StatesTaking people
- Overlook HospitalSummit, United StatesNo longer taking part
- Palo Alto Medical Foundation-SunnyvaleSunnyvale, United StatesTaking people
- Scott and White Memorial HospitalTemple, United StatesTaking people
- Montefiore Medical Center-Einstein CampusThe Bronx, United StatesTaking people
- Houston Methodist The Woodlands HospitalThe Woodlands, United StatesTaking people
- City of Hope South BayTorrance, United StatesTaking people
- Torrance Memorial Physician Network - Cancer CareTorrance, United StatesTaking people
- Smilow Cancer Hospital-Torrington Care CenterTorrington, United StatesTaking people
- Munson Medical CenterTraverse City, United StatesTaking people
- Upper Valley Medical CenterTroy, United StatesTaking people
- Smilow Cancer Hospital Care Center-TrumbullTrumbull, United StatesTaking people
- Banner University Medical Center - TucsonTucson, United StatesTaking people
- University of Arizona Cancer Center-North CampusTucson, United StatesTaking people
- Vince Lombardi Cancer Clinic-Two RiversTwo Rivers, United StatesTaking people
- SMC Center for Hematology Oncology UnionUnion, United StatesTaking people
- Memorial Sloan Kettering NassauUniondale, United StatesTaking people
- UPMC Cancer Center-UniontownUniontown, United StatesTaking people
- City of Hope UplandUpland, United StatesTaking people
- Carle Cancer CenterUrbana, United StatesTaking people
- Sutter Solano Medical Center/Cancer CenterVallejo, United StatesTaking people
- Essentia Health Virginia ClinicVirginia, United StatesTaking people
- Northwestern Medicine Cancer Center WarrenvilleWarrenville, United StatesTaking people
- Illinois CancerCare - WashingtonWashington, United StatesTaking people
- George Washington University Medical CenterWashington D.C., United StatesTaking people
- MedStar Washington Hospital CenterWashington D.C., United StatesTaking people
- Smilow Cancer Hospital-Waterbury Care CenterWaterbury, United StatesTaking people
- Smilow Cancer Hospital Care Center - WaterfordWaterford, United StatesTaking people
- ProHealth Waukesha Memorial HospitalWaukesha, United StatesTaking people
- UW Cancer Center at ProHealth CareWaukesha, United StatesTaking people
- Aurora Cancer Care-Milwaukee WestWauwatosa, United StatesTaking people
- AdventHealth Infusion Center WeavervilleWeaverville, United StatesTaking people
- Aurora West Allis Medical CenterWest Allis, United StatesTaking people
- Froedtert West Bend Hospital/Kraemer Cancer CenterWest Bend, United StatesTaking people
- Smilow Cancer Hospital Care Center - WesterlyWesterly, United StatesTaking people
- Geisinger Wyoming Valley/Henry Cancer CenterWilkes-Barre, United StatesTaking people
- Divine Providence HospitalWilliamsport, United StatesTaking people
- Minnesota Oncology Hematology PA-WoodburyWoodbury, United StatesTaking people
- University of Michigan Health - WestWyoming, United StatesTaking people
- Rush-Copley Healthcare CenterYorkville, United StatesNo longer taking part
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor CampusYpsilanti, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Alliance for Clinical Trials in Oncology
- Trial code
- NCT06661720
- Record updated
- 3 November 2026
- Original description
This phase III trial compares the effect of adding tivozanib to standard therapy pembrolizumab versus pembrolizumab alone for the treatment of patients with high-risk renal cell carcinoma (RCC). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Tivozanib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals tumor cells to multiply. This helps stop the spread of tumor cells. Giving pembrolizumab and tivozanib together may work better than pembrolizumab alone in treating patients with RCC.Read full original descriptionShow less
Short TeRm Intensified Pembrolizumab (KEytruda) and Tivozanib for High-Risk Renal Cell Carcinoma - STRIKE
This phase III trial compares the effect of adding tivozanib to standard therapy pembrolizumab versus pembrolizumab alone for the treatment of patients with high-risk renal cell carcinoma (RCC). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Tivozanib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals tumor cells to multiply. This helps stop the spread of tumor cells. Giving pembrolizumab and tivozanib together may work better than pembrolizumab alone in treating patients with RCC.
Inclusion: • Histologically confirmed diagnosis of RCC with clear cell component with or without sarcomatoid features following complete resection of the primary tumor (radical or partial nephrectomy); Note: Patients with microscopically positive soft tissue or vascular margins without gross residual disease are permitted; Intermediate-high risk RCC:; pT2 grade 4 or sarcomatoid features, N0M0; pT3 any grade N0, M0; High-risk RCC; pT4, any grade, N0, M0; pT, any stage., any grade, N+, M0; cM1 no evidence of disease (NED) RCC; Participants who have had resection of primary tumor (radical or partial nephrectomy) and resection or definitive radiation or ablation of solid, isolated, soft tissue metastases (excluding brain and bone lesions) at the time of primary tumor removal (synchronous) or ≤1 year from primary tumor removal (metachronous); Surgery (radical or partial nephrectomy or metastasectomy or ablation) > 4 weeks but =< 16 weeks prior to study registration with no ongoing complications from surgery; No evidence of disease at time of randomization as assessed by investigator by either CT or MRI scan of the brain and chest, abdomen and pelvis; No prior systemic treatment for RCC; Age >= 18 years; Eastern Cooperative Oncology Group (ECOG) performance status =< 2 (or Karnofsky >= 60%); Absolute neutrophil count (ANC) >= 1,000/mm\^3; Platelet count >= 100,000/mm\^3; Hemoglobin >= 8 g/dL; Total bilirubin =< 3 x upper limit of normal (ULN); Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 3 x upper limit of normal (ULN); Calculated (calc.) creatinine clearance >= 30 mL/min (using Cockcroft Gault equation or the estimated glomerular filtration rate from the modification of diet in renal disease trial); Urine protein =< 1+ on urine analysis (UA) or urine protein creatinine ration (UPCR) < 2mg/mg; Not pregnant and not nursing, because this study involves an agent that has known genotoxic, mutagenic and teratogenic effects. Therefore, for women of childbearing potential only, a negative pregnancy test is required =< 14 days prior to registration; HIV status: HIV-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial; Hepatitis; Hepatitis B: For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated. Patients with resolved HBV infection, defined as positive hepatitis B core antibody (anti-HBc) and negative hepatitis B surface antigen (HbsAg), are eligible; Hepatitis C: Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load; Cardiac Disease: Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class IIB or better; No history of myocarditis; No history of clinically significant pneumonitis; No uncontrolled hypertension (systolic blood pressure [BP] > 150 mm Hg or diastolic BP > 90 mm Hg) documented on 2 consecutive measurements taken at least 2 hours apart; No serious non-healing wound, ulcer or bone fracture within 28 days prior to registration; No serious/active infection requiring parenteral antibiotics; No moderate or severe hepatic impairment (child-Pugh B or C); No significant bleeding disorders within 1 month prior to registration, for example:; Hematemesis, hematochezia or other gastrointestinal bleeding grade 3 or higher; Hemoptysis of pulmonary bleeding grade 3 or higher; Hematuria or other genitourinary bleeding grade 3 or higher; No history of allogeneic organ transplantation; No history of allergy of hypersensitivity to study drugs or components; No condition requiring systemic treatment with either corticosteroid (> 10 mg daily or prednisone equivalent) within 14 days of treatment initiation or other immunosuppressive medications within 30 days of randomization. Inhaled or topical steroids and adrenal replacement doses ≤10 mg daily prednisone equivalent are permitted in absence of active autoimmune disease; No active peptic ulcer disease, inflammatory bowel disease, ulcerative colitis or other gastrointestinal condition associated with increased risk of perforation; history of abdominal fistula, gastrointestinal perforation or intra-abdominal abscess within 4 weeks prior to registration; Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial; No patients with a history of autoimmune disease that has required systemic treatment in the past 2 years (i.e., with use of disease modifying agents, corticosteroids > 10 mg/day, or immunosuppressive drugs) with the following exceptions:; Replacement therapy (e.g., thyroxine, insulin, physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is not considered a form of systemic treatment and is allowed; Brief (<7 days) use of systemic corticosteroids is allowed when use is considered standard of care; Patients with vitiligo, psoriasis, type 1 diabetes mellitus, hypothyroidism, or resolved childhood asthma/atopy will not be excluded; Patients requiring intermittent use of bronchodilators, inhaled steroids, or local steroid injections will not be excluded; Patients with hypothyroidism that is stable with hormone replacement or Sjögren's syndrome will not be excluded • Chronic concomitant treatment with strong CYP3A4 inducers is not allowed. Patients must discontinue the drug 14 days prior to the start of study treatment.