Studies Genes, Proteins and Metabolites in Drug-resistant Epilepsy
Compares brain tissue from people with hard-to-treat epilepsy and brain injury to normal tissue.
Plain-language title generated from the registry record
Registry title: Genes, Proteins, and Metabolites in Drug-resistant Epilepsy (DRE) Patients
Key facts
- Where
- Beijing, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 14 and 60 years old?
Source: NCT06665880, who can take part
Where in China
- Xuanwu Hospital, Capital Medical UniversityBeijing, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Xuanwu Hospital, Beijing
- Trial code
- NCT06665880
- Record updated
- 30 October 2024
- Original description
In patients with drug-resistant epilepsy (DRE), there may be changes at the genetic, proteomic, and metabolomic levels when comparing epileptic tissues from DRE to normal tissues in traumatic brain injury (TBI). These changes could help in understanding the pathophysiological mechanisms of epilepsy and in identifying new therapeutic targets.Read full original descriptionShow less
The Changes of Genes, Proteins, and Metabolites in Patients with Drug-resistant Epilepsy
In patients with drug-resistant epilepsy (DRE), there may be changes at the genetic, proteomic, and metabolomic levels when comparing epileptic tissues from DRE to normal tissues in traumatic brain injury (TBI). These changes could help in understanding the pathophysiological mechanisms of epilepsy and in identifying new therapeutic targets.
Inclusion: 14-60 years old, male or female, Han Chinese; Drug-resistant epilepsy; Required surgical implantation of SEEG electrodes.
Exclusion: Severe side effects from taking antiepileptic drugs at the time of enrollment and not inappropriate for SEEG; Significant heart, liver, renal insufficiency, and other medical diseases; A history of alcohol and drug abuse; Progressive encephalopathy or progressive structural damage in the central nervous system; Significant intellectual disability; Any contraindication to MRI.