Tests extra oxygen for adults with stroke transferred for clot removal
Tests extra oxygen therapy in adults with ischemic stroke before clot removal.
Plain-language title generated from the registry record
Registry title: Normobaric Oxygen in AIS Transferred for EVT
Key facts
- Where
- Baoji, Beijing, Cangzhou, Dali, Dexing, Enshi, Fuzhou, Guangzhou, Handan, Hezhou, Huanggang, Ji’an, Jinzhong, Jiujiang, Kunming, Liaocheng, Lichuan, Lüliang, Luoyang, Lushancun, Mudanjiang, Nanchang, Ningde, Putian, Qujing, Shangrao, Tai’an, Taiyuan, Xuanwei, Yichun, Yima, Yingtan, Yuxi, Zhangshu, Zhangzhou, and Zhoukou, ChinaSee the 112 sites
- Phase
- Phase 3
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with a new acute stroke who are being transferred to another hospital for thrombectomy. They would get extra oxygen (normobaric oxygen) or usual care.
- Age
- 18 years or older
- Sex
- All sexes
- Disease stage
- New acute ischemic stroke, within 9 hours of onset (last seen well). NIHSS score of 6 or more with a blocked large brain artery (ICA, MCA-M1 or MCA-M2) or a hyperdense MCA sign, or NIHSS score of 12 or more. ASPECTS at least 6.
- Earlier treatment
- No prior stroke in the last 3 months. No significant disability before the stroke (pre-stroke mRS 0-1). Not receiving other brain-protective drugs. Not in another treatment trial now or within the last 30 days.
Main reasons for not taking part
- Severe chronic lung disease, heart failure class III or IV, or lung infection
- Needs oxygen to keep SaO2 above 95%, or is intubated
- Bleeding in the brain on CT/MRI, or signs of subarachnoid hemorrhage
- Seizure at stroke onset, or rapidly improving symptoms
- Known pregnancy or positive pregnancy test, or life expectancy under 90 days
Read by machine on 12 November 2026.
Where in China
- Baoji High-Tech HospitalBaoji, ChinaContact: Wenjuan LiTaking people
- Caijiapo HospitalBaoji, ChinaContact: Yanan YangTaking people
- Longxian People's HospitalBaoji, ChinaContact: Zhen ZhangTaking people
- Meixian Traditional Chinese Medicine HospitalBaoji, ChinaContact: Huaijun YuanNot yet recruiting
- Xuanwu Hospital, Capital Medical UniversityBeijing, ChinaContact: Wenbo Hu, MDTaking people
- Cangzhou Central HospitalCangzhou, ChinaContact: Jing WangTaking people
- Dongguang County People's HospitalCangzhou, ChinaContact: Hongliang GuoTaking people
- Xianxian Traditional Chinese Medicine HospitalCangzhou, ChinaContact: Mei'e LiTaking people
- Binchuan County People's HospitalDali, ChinaContact: Ronglu YangTaking people
- Binchuan County Traditional Chinese Medicine HospitalDali, ChinaContact: Si YangTaking people
- Dali Prefecture People's HospitalDali, ChinaContact: Shiyu ZouTaking people
- Heqing County People's HospitalDali, ChinaContact: Linglin HuangTaking people
- Jianchuan County People's HospitalDali, ChinaContact: Junhua ZhangTaking people
- Midu County People's HospitalDali, ChinaContact: Zhimin ZhaoTaking people
- Nanjian Yi Autonomous County People's HospitalDali, ChinaContact: Guangqin LiTaking people
- Yangbi County People's HospitalDali, ChinaContact: Ye ChenTaking people
- Yongping County People's HospitalDali, ChinaContact: Yuhua ZhangTaking people
- Dexing People's HospitalDexing, ChinaContact: Rong HuangTaking people
- Hubei Minzu University Affiliated Minzu HospitalEnshi, ChinaContact: Changhua Qu, MDTaking people
- Fujian Medical University First Affiliated HospitalFuzhou, ChinaContact: Kunxin LinTaking people
- Fujian Medical University Union HospitalFuzhou, ChinaContact: Rongrong GaoTaking people
- Fujian Minhou County HospitalFuzhou, ChinaContact: Bixia ZhangTaking people
- Fuqing HospitalFuzhou, ChinaContact: Erqiang WangTaking people
- Fuqing Second HospitalFuzhou, ChinaContact: Feihong WangTaking people
- Fuzhou Changle District People's HospitalFuzhou, ChinaContact: Rongzeng Lin, MDTaking people
- Fuzhou Traditional Chinese Medicine HospitalFuzhou, ChinaContact: Wei HuangTaking people
- Guangchang County People's HospitalFuzhou, ChinaContact: Minghui ZhouTaking people
- Jinxi County People's HospitalFuzhou, ChinaContact: Guosheng ZhangTaking people
- Lianjiang County General HospitalFuzhou, ChinaContact: Yan ZhangTaking people
- Luoyuan County HospitalFuzhou, ChinaContact: Wenbing ChenTaking people
- Minqing County General HospitalFuzhou, ChinaContact: Yongwen LiuTaking people
- Yongtai County HospitalFuzhou, ChinaContact: Zaijun HeTaking people
- Zixi County People's HospitalFuzhou, ChinaContact: Peng ZhaoTaking people
- Guangzhou Development District HospitalGuangzhou, ChinaContact: Shouxi DengTaking people
- Guangzhou He Xian Memorial HospitalGuangzhou, ChinaContact: Mei QiTaking people
- Jinan University First Affiliated HospitalGuangzhou, ChinaContact: Guan Min, MDTaking people
- Yifeng County People's HospitalGuangzhou, ChinaContact: Shouxi DengTaking people
- Daming County Traditional Chinese Medicine HospitalHandan, ChinaContact: Jintao GuoTaking people
- Handan Central Hospital (East Campus)Handan, ChinaContact: Tingting WuTaking people
- Handan Fourth HospitalHandan, ChinaContact: Fei GaoTaking people
- Linzhang County People's HospitalHandan, ChinaContact: Linhua LiTaking people
- Quzhou County HospitalHandan, ChinaContact: Fan ChenTaking people
- Fuchuan Yao Autonomous County Ethnic Medicine HospitalHezhou, ChinaContact: Junguo HeTaking people
- Hezhou Traditional Chinese Medicine HospitalHezhou, ChinaContact: Muliang HeTaking people
- Zhaoping County People's HospitalHezhou, ChinaContact: Hongyi Luo, MDTaking people
- Huangmei County People's HospitalHuanggang, ChinaContact: Xinping XuTaking people
- Xiajiang County People's HospitalJi’an, ChinaContact: Xiang XuTaking people
- Xingan County People's HospitalJi’an, ChinaContact: Kewen Ge, MDTaking people
- Yongfeng County Traditional Chinese Medicine HospitalJi’an, ChinaContact: Jian Fu, MDTaking people
- Jincheng First People's HospitalJinzhong, ChinaContact: Junjie SongTaking people
- Xiyang County People's HospitalJinzhong, ChinaContact: Pengfei YueTaking people
- Dean County People's HospitalJiujiang, ChinaContact: Ping'an DengTaking people
- Dean County Traditional Chinese Medicine HospitalJiujiang, ChinaContact: Lan WangTaking people
- Hukou County People's HospitalJiujiang, ChinaContact: Jianfei KeTaking people
- Jiujiang First People's HospitalJiujiang, ChinaContact: Gang LiTaking people
- Pengze County People's HospitalJiujiang, ChinaContact: Aiyuan XuTaking people
- Chenggong District People's HospitalKunming, ChinaContact: Jizheng ZouTaking people
- Jinning District People's HospitalKunming, ChinaContact: Xiaoliu LiTaking people
- Kunming Medical University Yan'an HospitalKunming, ChinaContact: Haixin ChenTaking people
- Songming County People's HospitalKunming, ChinaContact: Lihong YangTaking people
- Yiliang First People's HospitalKunming, ChinaContact: Hongbo JiangTaking people
- Yunnan Provincial First People's HospitalKunming, ChinaContact: Da LiuTaking people
- Liaocheng People's HospitalLiaocheng, ChinaContact: Xiukai GuoTaking people
- Lichuan Traditional Chinese Medicine HospitalLichuan, ChinaContact: Yi Chen, MDTaking people
- Wenshui County People's HospitalLüliang, ChinaContact: Haixia An, MDTaking people
- Luoyang Central HospitalLuoyang, ChinaContact: Jiangwei Feng, MDTaking people
- Song County People's HospitalLuoyang, ChinaContact: Junfeng DongTaking people
- Xin'an County People's HospitalLuoyang, ChinaContact: Yumin YanTaking people
- Yichuan County People's HospitalLuoyang, ChinaContact: Yali GuoTaking people
- Lushan People's HospitalLushancun, ChinaContact: Ping XiongTaking people
- Linkou County People's HospitalMudanjiang, ChinaContact: Zhenguo XingTaking people
- Mudanjiang Second People's HospitalMudanjiang, ChinaContact: Yongxu YangTaking people
- Anyi County People's HospitalNanchang, ChinaContact: Muyin DaiTaking people
- Jiangxi Provincial People's HospitalNanchang, ChinaContact: Qingping ZhouTaking people
- Xinjian District People's HospitalNanchang, ChinaContact: WangTaking people
- Gutian County HospitalNingde, ChinaContact: Jie ChenTaking people
- Putian Hanjiang District HospitalPutian, ChinaContact: Wanfu He, MDTaking people
- Fuyuan County People's HospitalQujing, ChinaContact: xianghua LiuTaking people
- Shizong County People's HospitalQujing, ChinaContact: Chao LiangTaking people
- The First People's Hospital Of QujingQujing, ChinaContact: Sanxi Lei, MDTaking people
- Poyang County People's HospitalShangrao, ChinaContact: Guobin ZhangTaking people
- Wannian County People's HospitalShangrao, ChinaContact: FangTaking people
- Feicheng Hospital of Shandong Yiyang Health GroupTai’an, ChinaContact: Changliang ChangTaking people
- Shanxi Provincial People's HospitalTaiyuan, ChinaContact: Tao ZhouTaking people
- Xuanwei First People's HospitalXuanwei, ChinaContact: Xiangxuan HeTaking people
- Fengxin County People's HospitalYichun, ChinaContact: Aihua YuTaking people
- Shanggao County People's HospitalYichun, ChinaContact: Jun Yuan, MDTaking people
- Yima People's HospitalYima, ChinaContact: Wenjing ZhaoTaking people
- Yimei General HospitalYima, ChinaContact: ZhangTaking people
- Yujiang District People's HospitalYingtan, ChinaContact: Mingfa ChenTaking people
- Yuxi Zhongshan HospitalYuxi, ChinaContact: Qiqi Wei, MDTaking people
- Zhangshu People's HospitalZhangshu, ChinaContact: Sizhen AoTaking people
- Dongshan County HospitalZhangzhou, ChinaContact: Xinping XuTaking people
- Nanjing County HospitalZhangzhou, ChinaContact: Weiqi XuTaking people
- Pinghe County HospitalZhangzhou, ChinaContact: Haibin YanTaking people
- Xiage Health CenterZhangzhou, ChinaContact: Suyan HuangTaking people
- Yunxiao County HospitalZhangzhou, ChinaContact: Shengbin ChenTaking people
- Yunxiao County Traditional Chinese Medicine HospitalZhangzhou, ChinaContact: Shengbin Chen, MDTaking people
- Zhangpu County HospitalZhangzhou, ChinaContact: Wenhua LiTaking people
- Zhangpu County Traditional Chinese Medicine HospitalZhangzhou, ChinaContact: Jinyong XuTaking people
- Zhangzhou Changtai District HospitalZhangzhou, ChinaContact: Wenchao DaiTaking people
- Zhangzhou Fifth HospitalZhangzhou, ChinaContact: Changfu LinTaking people
- Zhangzhou Gulei Port Economic Development Zone First HospitalZhangzhou, ChinaContact: Linquan ZhengTaking people
- Zhangzhou HospitalZhangzhou, ChinaContact: Jingyu ChenTaking people
- Zhangzhou Hospital Headquarters (High-Tech Campus)Zhangzhou, ChinaContact: Weifeng HuangTaking people
- Zhangzhou Second HospitalZhangzhou, ChinaContact: Shaohua LinTaking people
- Zhao'an County HospitalZhangzhou, ChinaContact: Yongbo LinTaking people
- Danchuan Central HospitalZhoukou, ChinaContact: Wenzhong LiTaking people
- Danchuan County Traditional Chinese Medicine HospitalZhoukou, ChinaContact: Zhen WangTaking people
- Luyi Zhenyuan HospitalZhoukou, ChinaContact: Yinliang PanTaking people
- Shenqiu County People's HospitalZhoukou, ChinaContact: Yanling LiTaking people
- Zhoukou Central HospitalZhoukou, ChinaContact: Yan SunTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Capital Medical University
- Trial code
- NCT06666764
- Record updated
- 11 December 2025
- Original description
The primary objective of this study is to estimate the efficacy and safety of NBO on 3-month functional outcome after acute ischemic strokeRead full original descriptionShow less
Adjuvant Normobaric Hyperoxia in Acute Ischemic Stroke Patients Transferred for Thrombectomy
The primary objective of this study is to estimate the efficacy and safety of NBO on 3-month functional outcome after acute ischemic stroke
Inclusion: Age at least 18 years old; Signs and symptoms are consistent with a new acute stroke, with low possibility of stroke mimics (e.g., no sudden coma, prior seizure disorder, suspected hypoglycemia); No prior stroke in the last 3 months; Time from stroke onset (last seen well) to randomization is within 9 hours; (1) Baseline NIHSS score at 6 or more and Intracranial ICA or MCA-M1 or MCA-M2 dominant occlusion, with or without tandem cervical carotid stenosis or tandem cervical occlusion, confirmed by preoperative CTA (or MRA, DSA) and consistent with signs and symptoms; or (2) Baseline NIHSS score at 6 or more with a hyperdense MCA sign on non-contrast CT; or (3) Baseline NIHSS score at 12 or more; NIHSS score 0 or 1 in the section of level of consciousness; No significant pre-stroke disability (pre-stroke mRS 0--1); ASPECTS at least 6 on non-contrast CT; Patient is planned for transfer to a EVT-capable hospital for EVT; Signed informed consent from the patient or the legally authorized representative (LAR).
Exclusion: Known history of severe chronic obstructive pulmonary disease (FEV1 less than 1.0), New York Heart Association (NYHA) Heart Failure Class III or IV, acute pulmonary infection or aspiration pneumonia, prior to enrollment; Rapidly improving neurological deficits or transient ischemic attack prior to consent; Participating in another clinical treatment trial, or completed participation within prior 30 days; Receiving other cerebral protective agent (e.g., edaravone dexborneol, n-butylphthalide); Seizure at stroke onset; Signs and symptoms suggestive of subarachnoid hemorrhage, even if CT scan is normal; Evidence of acute intracranial hemorrhage on CT/MRI; Respiratory rate <= 10 or >= 30 breaths per minute; Oxygen-dependence at baseline to maintain SaO2 > 95% or intubation at baseline; Exhibiting symptoms of vomiting, or severe headache, or unconscious; Evidence of intracranial tumor (except small meningioma) or arteriovenous malformation; Woman of childbearing potential known to be pregnant or with a positive pregnancy test; Life expectancy < 90 days due to comorbidity; Unlikely to complete the 90-day follow-up; Significant mass effect with midline shift, defined as any deviation of midline structures such as the septum pellucidum, is observed on CT/MRI scans.