Tests exercise training and muscle changes in people with head and neck cancer

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with head and neck squamous cell cancer who need chemoradiotherapy. They will do 36 exercise training sessions afterwards.

Age

20 to 80 years

Sex

All sexes

Disease stage

Squamous cell carcinoma of the head and neck that needs concurrent chemoradiotherapy (CCRT). ECOG PS below 2.

Earlier treatment

Must need concurrent chemoradiotherapy (CCRT). No other earlier treatment is named.

Main reasons for not taking part

• ECOG PS 2 or higher
• Cannot tolerate basic exercise training, or does not get CCRT
• Mental or medical illness that exercise could make worse or that cannot be managed
• Any medical condition that makes exercise training unsuitable
• Whole-body CT data cannot be obtained

The registry criteria, word for word

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

• Are you between 20 and 80 years old?YesNo

What the trial wants to find out

This project adopts a prospective study design. It is scheduled to enroll 60 participants diagnosed with Head and Neck cancer in this hospital, of which 30 are in the experimental group and 30 are in the control group. The purpose of this research is to analyze the skeletal muscle mass changes on images in Head and Neck cancer patients after exercise training and the association with systemic inflammatory markers. Investigators would like to know whether these images and biomarkers predict the prognosis of Head and Neck cancer. Subjects enrolled in the trial will receive 36 times of exercise training after concurrent chemoradiotherapy. Before and after the completion of exercise training, investigators will arrange (1) dual energy X-ray absorptiometry (DXA) to measure the whole-body skeletal muscle mass and appendicular skeletal muscle mass and (2) blood tests for markers of systemic inflammation. In addition to DXA, computed tomography (CT) is another image modality for skeletal muscle mass evaluation. Positron emission tomography - CT or whole-body CT for cancer staging are considered as baseline studies. The routine follow-up CT images are used to analyze the changes after exercise training. If magnetic resonance imaging is also performed during the follow-up period, images will also be collected and assessed as an alternative.If the experimental group can maintain or even improve skeletal muscle mass and can be reflected in blood tests and prognosis, the result may be able to apply on cancer treatment and disease followup.

The 2 groups in the trial

• controlNo study treatment, for comparison

  No Intervention: Head and Neck patients after CCRT treatment. After CCRT treatment, participants keep follow the skeletal muscle mass evaluation

• experimentalTreatment being tested

  Experimental: Head and Neck patients after CCRT treatment with exercise training. After CCRT treatment 4-5 week, arrange participants do the exercise training for patient. Two to three times a week ,total 24-36 times. Participants keep follow the skeletal muscle mass evaluation.

  Treatment: HIIT only and HIIT & Record of physical activities at home.