Tests JNJ-90301900 added to chemoradiation for lung cancer
Tests JNJ-90301900 with chemoradiation and durvalumab in adults with locally advanced lung cancer.
Plain-language title generated from the registry record
Registry title: A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)
Key facts
- Where
- Camperdown, Herston, Nedlands, North Ryde, and Parkville, AustraliaSee the 5 sites
- Phase
- Phase 2
Where in Australia
- Chris O'Brien LifehouseCamperdown, AustraliaTaking people
- Royal Brisbane and Women's HospitalHerston, AustraliaTaking people
- Sir Charles Gairdner HospitalNedlands, AustraliaTaking people
- Macquarie UniversityNorth Ryde, AustraliaTaking people
- Royal Melbourne HospitalParkville, AustraliaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Johnson & Johnson Enterprise Innovation Inc.
- Trial code
- NCT06667908EU 2024-518276-32-00
- Record updated
- 3 November 2026
- Original description
The purpose of this study is to determine whether JNJ-90301900 added to concurrent platinum-based doublet chemotherapy with radiation therapy (cCRT) followed by consolidation immunotherapy (cIT) can improve objective response rate (ORR; that is percentage of participants whose best response is complete response or partial response during the study) in participants with locally advanced and unresectable stage III non-small cell lung cancer.Read full original descriptionShow less
A Phase 2, Randomized, Open-Label, Active-Controlled Study of JNJ-90301900 in Combination With Chemoradiation Followed by Durvalumab in Locally Advanced and Unresectable Stage III NSCLC
The purpose of this study is to determine whether JNJ-90301900 added to concurrent platinum-based doublet chemotherapy with radiation therapy (cCRT) followed by consolidation immunotherapy (cIT) can improve objective response rate (ORR; that is percentage of participants whose best response is complete response or partial response during the study) in participants with locally advanced and unresectable stage III non-small cell lung cancer.
Inclusion: Must be a candidate for standard of care (SOC) treatment of non small cell lung cancer (NSCLC) by concurrent platinum-based doublet chemotherapy with radiation therapy (cCRT) followed by consolidation durvalumab treatment as determined by the investigator and per local guidelines at screening; Have a medical history of pathologically (histologically or cytologically) proven diagnosis of NSCLC within 3 months prior to enrollment/randomization; Have locally advanced unresectable stage III NSCLC according to the eighth edition lung cancer stage classification; Have at least 1 target lesion (primary lung lesion or involved lymph node[s]) per RECIST version 1.1 that is amenable to intratumoral and/or intranodal injection and intensity modulated radiation therapy (IMRT) as determined by the investigator at screening; Have an eastern cooperative oncology group (ECOG) performance status of 0 to 1.
Exclusion: Any of the following within 3 months prior to enrollment/randomization: severe or unstable angina, myocardial infarction, clinically significant ventricular arrhythmias or heart failure New York heart association functional classification class III to IV; Another concurrent or prior primary malignancy within the last 36 months at informed consent; Medical history of: (a) Primary immunodeficiency (b) Organ transplant that requires therapeutic immunosuppression; Known allergies, hypersensitivity, or intolerance to any ingredients of JNJ-90301900 crystalline solution, platinum-based doublet chemotherapy (ChT), or durvalumab; History of coagulation disorders, including: (a) Active bleeding diathesis or requirement for therapeutic anticoagulation or antiplatelet that cannot be interrupted or altered for JNJ-90301900 injection procedures, (b) Major thromboembolic events (for example, pulmonary embolism, cerebrovascular accident) within 3 months of enrollment or randomization.