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Non-Invasive Programmed Stimulation (NIPS) to Guide the Subsequent VT Therapeutic Strategies

Key facts

Who runs it
IRCCS Ospedale San Raffaele
Where
Italy1 site in 1 countryChoose a country to see its sites
Trial code
Status
Recruiting
People taking part
51 people, planned
Started
12 Jun 2025
Expected to end
Dec 2027
Type of study
Interventional, 2 groups
Treatments tested
  • Re-Do ventricular tachycardia ablation
  • Antiarrhythmic Drug Therapy (amiodarone, sotalol, or mexiletine)
Record updated
27 March 2026

Who can take part

Age
18 years and older
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 13 criteriaShow less

Who can take part

  • Patients with an implanted ICD (all brands)
  • Patients who underwent a successful (non-inducibility of any VT) Ventricular Tachycardia Ablation procedure, the "index procedure", supported by EnSite Precision or CARTO 3D mapping systems for the following etiologies: previous MI, myocarditis, ARVD, IDCM
  • Induction of monomorphic VT at NIPS 3-7days after a successful index procedure
  • Age 18 years or more
  • Able to provide an informed consent to participate to the study and available to respect the assessments described in the protocol

Who cannot take part

  • Recent (<3 months) myocardial infarction or unstable angina or Coronary Artery Bypass
  • Inducible VT after index procedure
  • Contraindication to anticoagulants
  • Presence of thrombi
  • Presence of Mitral and Aortic prosthetic valve
  • Pregnant or nursing
  • Ventricular Tachycardia caused by reversible pathology
  • < 1 Year life expectancy according to the investigator

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

The aim of this study is to define the importance of non-invasive programmed stimulation (NIPS) in risk stratification of ventricular tachycardia (VT) recurrence after catheter ablation and to determine the optimal treatment strategy. The primary objective is to establish whether a new VT ablation based on NIPS inducibility will reduce the risk of VT recurrence compared to antiarrhythmic drug therapy.

The 2 groups in the trial

  • Group 1Treatment being tested

    AAD therapy

    Treatment: Antiarrhythmic Drug Therapy (amiodarone, sotalol, or mexiletine)

  • Group 2Treatment being tested

    Re-Do ablation procedure

    Treatment: Re-Do ventricular tachycardia ablation

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
The Value of Late Non-Invasive Programmed Stimulation (NIPS) in the Setting of Ventricular Tachycardia (VT) Ablation to Guide the Subsequent VT Therapeutic Strategies: a Prospective Randomized Multicenter Study
Record updated
27 March 2026