Comparing Two Breathing Support Methods After Breathing Tube Removal in Heart Failure
Compares high-flow nasal cannula with noninvasive ventilation in adults with systolic heart failure after extubation.
Plain-language title generated from the registry record
Registry title: A Trial Comparing High-Flow Nasal Cannula Versus Noninvasive Ventilation on Reintubation and Post-Extubation Respiratory Failure in High-Risk Patients With Systolic Heart Failure
Key facts
- Where
- New Haven, United StatesSee the site
Where in United States
- Yale New Haven Hospital (CICU or MICU)New Haven, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Yale University
- Trial code
- NCT06671015
- Record updated
- 28 May 2026
- Original description
This prospective, open-label randomized controlled pilot trial will enroll participants at the Yale New Haven Hospital. Patients with systolic heart failure, defined as an ejection fraction ≤40%, who require invasive mechanical ventilation (IMV) and are admitted to either the cardiac intensive care unit (CICU) or medical ICU (MICU) will be included.Read full original descriptionShow less
A Prospective Randomized Controlled Trial Comparing High-Flow Nasal Cannula Versus Noninvasive Ventilation on Reintubation and Post-Extubation Respiratory Failure in High-Risk Patients With Systolic Heart Failure
This prospective, open-label randomized controlled pilot trial will enroll participants at the Yale New Haven Hospital. Patients with systolic heart failure, defined as an ejection fraction ≤40%, who require invasive mechanical ventilation (IMV) and are admitted to either the cardiac intensive care unit (CICU) or medical ICU (MICU) will be included.
Subjects meeting eligibility criteria will be randomized 1:1 to one of the two treatment groups:
* Intervention: Extubation to high-flow nasal cannula (HFNC) * Control: Extubation to non-invasive ventilation (NIV)
Inclusion: The patient is a male or non-pregnant female greater than or equal to 18 years of age; The patient is ventilated for greater than 24 hours; The patient has a systolic left ventricular dysfunction defined as an ejection fraction less than or equal to 40%; The patient, or legally authorized representative, has been informed of the nature of the study, agrees to its provisions, and has provided written informed consent, approved by the appropriate Institutional Review Board (IRB) or Ethics Committee (EC).
Exclusion: Patients with pre-existing NIV prescription (e.g., obstructive sleep apnea, neuromuscular disorders, advanced COPD); Patients actively being treated for a COPD exacerbation or known hypercapnia (PaCO2>45) on last Arterial Blood Gas (ABG); Patients agitated or uncooperative state; Patients with do-not-resuscitate orders; Patients presenting with tracheostomies or anatomical abnormalities interfering with mask fit; Patients are prisoners; Patient self-extubates.