Genetic Variants Associated With the Risk of Gall Stones and Cirrhosis.
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- Who runs it
- Institute of Liver and Biliary Sciences, India
- Trial code
- NCT06679738
- Record updated
- 7 November 2024
- Original description
Gall stone disease is more common in patients with cirrhosis. This association has been well established in different studies. Among the various factors which predispose a patient with gall stone disease to have associated liver cirrhosis, genetics also plays an important role.Read full original descriptionShow less
Gall stone disease is more common in patients with cirrhosis. This association has been well established in different studies. Among the various factors which predispose a patient with gall stone disease to have associated liver cirrhosis, genetics also plays an important role.
This study aims to do a genetic panel-based analysis of genes which are involved in cholestasis to find any association between liver cirrhosis and gall stone disease.
Patients with history of gall stone or history of cholecystectomy done for gall stone disease will be evaluated for the presence of liver cirrhosis by fibroscan and ultrasonography. Those patients with cirrhosis and without cirrhosis will undergo a panel based genetic test for the common cholestasis genes and multivariate analysis will be done for variants associated with lithogenesis and cirrhosis.
Inclusion: Patients > 18 years of age; Who has a GSD diagnosed by USG or have history of cholecystectomy for gall stone disease; Who is a diagnosed case of cirrhosis by Fibroscan or USG (Cirrhosis including alcohol related cirrhosis, Hepatitis B, Hepatitis C, Wilsons disease, Hemochromatosis are excluded.
Exclusion: Patients who has a diagnosed cause for liver disease, including alcohol related cirrhosis, Hepatitis B, Hepatitis C, Wilsons disease, Hemochromatosis; Patients who have haemolytic anaemia; Patients who do not consent for genetic study; Inability to provide informed consent; Cannot understand Hindi or English should be excluded since they will not be able to reply objectively to questionnaire.