Continued vutrisiran treatment for adults with heart disease from transthyretin amyloidosis
Studies vutrisiran in adults with transthyretin amyloidosis and heart muscle disease, continuing or switching treatment.
Plain-language title generated from the registry record
Registry title: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy
Key facts
- Where
- Barcelona, Bilbao, L'Hospitalet de Llobregat, Madrid, and Málaga, SpainSee the 5 sites
- Phase
- Phase 3
Where in Spain
- BarcelonaBarcelona, SpainNo longer taking part
- BilbaoBilbao, SpainNo longer taking part
- L'Hospitalet de LlobregatL'Hospitalet de Llobregat, SpainNo longer taking part
- MadridMadrid, SpainNo longer taking part
- MálagaMálaga, SpainNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Alnylam Pharmaceuticals
- Trial code
- NCT06679946
- Record updated
- 21 October 2026
- Original description
The purpose of this study is to obtain safety, efficacy, and pharmacodynamic data on the use of vutrisiran in patients with ATTR amyloidosis with cardiomyopathy who continued on extended use of vutrisiran, or switched from patisiran.Read full original descriptionShow less
An Open-Label Extension Study to Assess the Safety and Efficacy of Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy (ATTR Amyloidosis With Cardiomyopathy)
The purpose of this study is to obtain safety, efficacy, and pharmacodynamic data on the use of vutrisiran in patients with ATTR amyloidosis with cardiomyopathy who continued on extended use of vutrisiran, or switched from patisiran.
Inclusion: Patients who are participating in the patisiran parent studies ALN-TTR02-011 or ALN-TTR02-014 or who have completed the 24-month OLE Period in the vutrisiran parent study ALN-TTRSC02-003.
Exclusion: Has permanently discontinued study drug administration while participating in the parent studies, ALN-TTR02-011, ALN-TTR02-014, or ALN-TTRSC02-003; Future or current participation in another investigational device or drug study, scheduled to occur during this study; Has other medical conditions or comorbidities which, in the opinion of the Investigator, would interfere with study compliance or data interpretation.