Studies how often restless legs syndrome occurs in Thai people with Parkinson's disease
Observes restless leg symptoms in adults with Parkinson's disease, without giving any treatment.
Plain-language title generated from the registry record
Registry title: Prevalence and Characteristics of Restless Leg Syndrome in Thai Patients With Parkinson's Disease
Key facts
- Where
- Bangkok, ThailandSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT06684782, who can take part
Where in Thailand
- Siriraj Hospital Mahidol UniversityBangkok, ThailandTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Siriraj Hospital
- Trial code
- NCT06684782
- Record updated
- 15 May 2025
- Original description
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by pathologic intraneuronal alpha-synuclein-positive Lewy bodies and neuronal cell loss. The cardinal clinical symptoms and signs of PD are bradykinesia, rigidity, tremor, postural instability, and freezing attacks. The prevalence of PD increases with age, affecting 1-2% of the population over the age of 65 years, and 3% of those over 85 years.Read full original descriptionShow less
Prevalence and Characteristics of Restless Leg Syndrome in Thai Patients With Parkinson's Disease
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by pathologic intraneuronal alpha-synuclein-positive Lewy bodies and neuronal cell loss. The cardinal clinical symptoms and signs of PD are bradykinesia, rigidity, tremor, postural instability, and freezing attacks. The prevalence of PD increases with age, affecting 1-2% of the population over the age of 65 years, and 3% of those over 85 years.
Restless legs syndrome (RLS) represents disturbing symptoms in lower limbs that lead to the urge to move, occurring in rest periods. Movements can partially or completely relieve these abnormal feelings. In 2014, the International RLS Study Group (IRLSSG) established five mandatory criteria for the diagnosis of RLS. Several studies supported that RLS and PD may share pathophysiological mechanisms.
Inclusion: Patients with Parkinson's disease aged from 18 to 80 years who met the United Kingdom Parkinson's Disease Society (UKPDS) Brain Bank Diagnostic criteria.
Exclusion: Patients with secondary causes of restless leg syndrome including end-stage renal disease, iron deficiency anemia and pregnancy; Patients with atypical or secondary parkinsonism; Patients with Mini-mental status exam (MMSE) less than 24 of 30.