NCT06685679CompletedPhase 3
Melatonin for Pulmonary Hypertension in Full Term Neonates
Melatonin as an Adjunct Therapy to Milrinone for Pulmonary Hypertension in Full Term Neonates
Source: ClinicalTrials.gov · Last updated 10 Jul 2025
Brief summary (registry, in English)
Published evidence has provided a possible role of melatonin and the treatment of pulmonary hypertension through its strong antioxidant properties and improving vascular function in animals. This study will test the hypothesis of the possible use of melatonin as an adjunct therapy to milrinone for neonatal pulmonary hypertension.
- Status (registry)
- Completed
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 40 (actual)
- First submitted
- 11 Nov 2024
- Start date
- 15 May 2024
- Primary completion date
- 15 Dec 2024
- Lead sponsor
- Ain Shams University
- NCT number
- NCT06685679
What you commit to
- Study type: Interventional · Phase 3
- Participants enrolled: 40
- From 15 May 2024 to the primary completion date, 15 Dec 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Neonates with major congenital anomalies like congenital heart diseases
- NPO or any contraindications to oral intake
- Neonates with suspected inborn error of metabolism
Who the study is looking for
- full term neonates ≥37 weeks diagnosed with pulmonary hypertension, with Pulmonary arterial pressure (PAP) \> 25 mm Hg measured by echocardiography, within 72 h of birth (Chetan et al., 2022).
Age in the registry: - to 28 days · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ain Shams University Coordinator of this site? Confirm its status | Cairo | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.