Imaging blood flow during stroke clot removal in patients with acute ischemic stroke
Studies a new 3D imaging method during clot removal in adults with ischemic stroke.
Plain-language title generated from the registry record
Registry title: PeRfusiOn Post tHrombEcTomy (PROPHET)
Key facts
- Where
- Basel and Bern, SwitzerlandSee the 2 sites
Where in Switzerland
- University Hospital BaselBasel, SwitzerlandNot yet recruiting
- University Hospital BernBern, SwitzerlandTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Insel Gruppe AG, University Hospital Bern
- Trial code
- NCT06691230
- Record updated
- 15 November 2024
- Original description
Endovascular mechanical thrombectomy is the standard of care for treating patients with a large-vessel occlusion acute ischemic stroke. However, in more than half of these patients, remaining distal vessel occlusions limit the benefit of this therapy. Currently the detection of residual vessel occlusions and the decision for further treatment by the operator is based on the 2D digital subtraction angiography (DSA) images. However, this technique has several limitations. Recently, a new imaging technique, with the possibility to acquire 3D time-resolved perfusion images directly in the operating room was introduced (the flat-panel detector computed tomography perfusion imaging, FDCTP). It can overcome the spatial limitations of 2D DSA, but the details on clinical validation and utility of FDCTP are currently lacking.Read full original descriptionShow less
PeRfusiOn Post tHrombEcTomy (PROPHET) A Prospective Observational Cohort Study
Endovascular mechanical thrombectomy is the standard of care for treating patients with a large-vessel occlusion acute ischemic stroke. However, in more than half of these patients, remaining distal vessel occlusions limit the benefit of this therapy. Currently the detection of residual vessel occlusions and the decision for further treatment by the operator is based on the 2D digital subtraction angiography (DSA) images. However, this technique has several limitations. Recently, a new imaging technique, with the possibility to acquire 3D time-resolved perfusion images directly in the operating room was introduced (the flat-panel detector computed tomography perfusion imaging, FDCTP). It can overcome the spatial limitations of 2D DSA, but the details on clinical validation and utility of FDCTP are currently lacking.
Inclusion: Informed consent as documented by a signature; The patients received mechanical thrombectomy or there was the intention to perform endovascular treatment, but only diagnostic angiography was performed; Patients received FDCTP as clinically indicated by the treating physician.
Exclusion: Inability to follow the clinically indicated visit at 90 days after the index stroke (e.g. patients living abroad); Inability to give consent due to insufficient knowledge of the project language.