Lying Face-Down While Awake for Severe Chest Syndrome in Sickle Cell Disease
Tests lying face-down while awake in adults with sickle cell and severe chest syndrome.
Plain-language title generated from the registry record
Registry title: Awake Prone Positioning for Severe Acute Chest Syndrome
Key facts
- Where
- Paris, FranceSee the site
Where in France
- Service de Médecine Intensive Réanimation TENONParis, FranceNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Assistance Publique - Hôpitaux de Paris
- Trial code
- NCT06698120
- Record updated
- 2 September 2025
- Original description
Acute chest syndrome (ACS) is the leading cause of admission to intensive care and the leading cause of death in patients with sickle cell disease. Irrespective of the cause of ACS, there is an heterogeneity in pulmonary ventilation/perfusion ratios, leading to worsening of the disease.Read full original descriptionShow less
Assessment of Efficacy and Safety of Awake Prone Positioning in Sickle Cell Anemia Patient Admitted in Intensive Care Unit for Severe Acute Chest Syndrome
Acute chest syndrome (ACS) is the leading cause of admission to intensive care and the leading cause of death in patients with sickle cell disease. Irrespective of the cause of ACS, there is an heterogeneity in pulmonary ventilation/perfusion ratios, leading to worsening of the disease.
Efficiency of awake prone positioning (APP) in acute respiratory failure (ARF) was particularly highlighted during the COVID-19 pandemic. Several physiological factors contribute to this benefit including an improvement in ventilatory drive and gas exchange.
The investigator hypothesize that APP could lead to clinical improvement in ACS in terms of oxygenation and ventilatory drive, by improving the heterogeneity of ventilation
Inclusion: Age >18 years; Major sickle cell anemia (SS, SC, Sβ); Admission in intensive care unit for ACS; Registered in the French social insurance regime; Written, informed consent.
Exclusion: Pregnant or breastfeeding women; Immediate need for intubation; Impaired vigilance status (Glasgow scale score < 12); Pneumothorax; Haemodynamically unstable; Thoracic trauma admission; Severely obese with body-mass index higher than 40 kg/m²; EIT contraindication: pacemaker, automatic implantable defibrillators, skin lesions facing the EIT belt, unstable rachis fracture or medullary lesions.