Longer versus shorter Clomid treatment before IVF in women with low egg supply
Compares longer and shorter Clomid use for ovarian stimulation in women with diminished ovarian reserve.
Key facts
- Who runs it
- University of Southern California
- Where
- Pasadena, United StatesSee the site
- Trial code
- Registry title
- Evaluation of a Long Versus Short Clomid Protocol for Controlled Ovarian Stimulation
- Status
- Recruiting
- Phase
- Phase 4
- People taking part
- 120 people, planned
- Started
- 1 Jun 2025
- Expected to end
- Jun 2028
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Clomiphene Citrate
- Record updated
- 4 August 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for women with low egg reserve in the ovaries (diminished ovarian reserve) who are having IVF. It compares a long Clomid schedule with a 5-day Clomid schedule.
- Age
- 18 to 44 years; the woman must be under 45 when stimulation starts.
- Sex
- Women only.
- Disease stage
- Female infertility with diminished ovarian reserve, meeting the POSEIDON criteria based on clinic evaluation. The woman must be undergoing IVF and planning a 36-hour trigger window. She must plan to freeze all embryos, or have a fresh transfer if placed in the short Clomid group.
- Earlier treatment
- People who had an egg released too early (premature ovulation) in the past cannot join.
- Biomarker or test result
- Antral follicle count (small follicles seen on ultrasound) of 2 or more. The male partner or sperm source cannot be azoospermic (no sperm in the semen).
Main reasons for not taking part
- Normal ovarian reserve or a good response to stimulation
- Allergy or bad reaction to Clomid
- Minimal stimulation protocols
- Past premature ovulation
The registry criteria, word for word
Show all 10 criteriaShow less
Who can take part
- Undergoing IVF
- Must meet POSEIDON criteria based on clinic evaluation
- Female partner: Antral follicle count of 2 or more and age <45 at time of stimulation start
- Male partner/sperm source: Cannot be azoospermic
- Planning freeze-all cycle (regardless of blastocyst or cleavage stage culture) or fresh transfer if randomized to short Clomid group
- Planning 36-hour trigger window
Who cannot take part
- History of prior premature ovulation
- Allergy or adverse reaction to Clomid
- Normal ovarian reserve or good response
- Minimal stimulation protocols
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 44 years old?
Where in United States
- HRC FertilityPasadena, United StatesContact: Bonnie Song, MDTaking people
About the trial
What the trial wants to find out
The goal of this clinical trial is to evaluate a long Clomid protocol as compared to a 5-day Clomid protocol for ovarian stimulation in patients with diminished ovarian reserve undergoing ovarian stimulation for in-vitro fertilization. The aim of the long Clomid protocol is to intensify stimulation of the ovaries and reduce both cost and injection burden for patients. Participants will be randomized to receive the long Clomid protocol vs. the typical protocol involving Clomid only for 5 days followed by growth hormone-releasing hormone (GnRH) antagonist. The primary outcome the investigators will evaluate will be the number of mature eggs retrieved.
The 2 groups in the trial
- Long ClomidTreatment being tested
Clomid with gonadotropins throughout the entire duration of ovarian stimulation without addition of GnRH antagonist
Treatment: Clomiphene Citrate
- 5-day ClomidExisting treatment, for comparison
Clomid only for 5 days at beginning of ovarian stimulation with gonadotropins, with GnRH antagonist added when the lead follicle reaches \~14mm.
Treatment: Clomiphene Citrate
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Evaluation of a Long Versus Short Clomid Protocol for Controlled Ovarian Stimulation in Patients With Diminished Ovarian Reserve Undergoing In-vitro Fertilization: a Randomized Controlled Trial
- Plain-language title
- Longer versus shorter Clomid treatment before IVF in women with low egg supplyGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 15 November 2026.
- Fit questions
- Built from NCT06701071, who can take part
- Record updated
- 4 August 2026