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Taking people in MalawiNo phase

Enhanced Problem-solving Therapy and HIV Engagement Support to Improve Perinatal Mental Health & HIV Outcomes in Malawi

Key facts

Where
Lilongwe, MalawiSee the 5 sites

Where in Malawi

  • Area 18 Health CenterLilongwe, MalawiNot yet recruiting
  • Area 25 Health CenterLilongwe, MalawiTaking people
  • Bwaila HospitalLilongwe, MalawiTaking people
  • Kawale Health CenterLilongwe, MalawiTaking people
  • Likuni Mission HosptialLilongwe, MalawiTaking people

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?
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Trial details

Who runs it
University of North Carolina, Chapel Hill
Trial code
NCT06702722
Record updated
29 April 2026
Original description
The main objective of the proposed study is to evaluate the effectiveness of the Enhanced Friendship Bench intervention to improve perinatal depression, HIV care engagement, and infant health outcomes among pregnant women with HIV and depression in Malawi.Read full original descriptionShow less

Enhanced Problem-solving Therapy and HIV Engagement Support to Improve Perinatal Mental Health and HIV Outcomes in Malawi: A Randomized Controlled Trial

The main objective of the proposed study is to evaluate the effectiveness of the Enhanced Friendship Bench intervention to improve perinatal depression, HIV care engagement, and infant health outcomes among pregnant women with HIV and depression in Malawi.

Inclusion: Presenting for antenatal care at one of our 5 recruitment sites; ≥ 18 years of age; ≤ 34 weeks gestation; HIV-positive, based on medical records; Initiating, re-initiating, or on established ART during index pregnancy; Elevated depressive symptoms as indicated by a EPDS score ≥10. The EPDS is widely used to assess perinatal mood disorders that has been validated in perinatal populations in Malawi with this cut point to identify probable perinatal depression.

Exclusion: Suicidal ideation evaluated as acute risk; Other health concerns requiring emergent response.

ClinicalTrials.gov NCT06702722