Testing blood, sputum and breath samples for lung cancer DNA
Studies whether tumor DNA and breath compounds can be found in adults with lung cancer.
Plain-language title generated from the registry record
Registry title: NSCLC Liquid Biopsies and Exhaled VOC
Key facts
- Where
- Hamilton, CanadaSee the site
Where in Canada
- St. Joseph's Healthcare HamiltonHamilton, CanadaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- St. Joseph's Healthcare Hamilton
- Trial code
- NCT06707519
- Record updated
- 22 April 2026
- Original description
The objective of the study is to determine the feasibility of recruiting participants and using sputum, Bronchoalveolar lavage (BAL) and exhaled Volatile Organic Compounds (VOC) in addition to blood, as biological samples for detecting mutations in extracted cell-free DNA in non-small cell lung cancer (NSCLC) patients, before and after surgery, and any recurrence within a 24-month postoperative follow-up period.Read full original descriptionShow less
A Prospective, Single Center Study to Test the Validity and Feasibility of Circulating Tumor DNA in Blood, Sputum and Alveolar Fluid, as Well as Exhaled Volatile Organic Compounds as Biomarkers in Non-Small Cell Lung Cancer
The objective of the study is to determine the feasibility of recruiting participants and using sputum, Bronchoalveolar lavage (BAL) and exhaled Volatile Organic Compounds (VOC) in addition to blood, as biological samples for detecting mutations in extracted cell-free DNA in non-small cell lung cancer (NSCLC) patients, before and after surgery, and any recurrence within a 24-month postoperative follow-up period.
This is a pilot feasibility study, proposed as a 24-month prospective, single-center, non-interventional, observational trial with NSCLC-adenocarcinoma patients indicated for resection surgery with curative intent.
Inclusion: Patient must be at least 18 years of age; Patient must be able to provide consent; Patients undergoing surgical resection with curative intent for non-small cell lung cancer at St. Joseph's Healthcare Hamilton and Firestone Institute for Respiratory Health.
Exclusion: Patients with previously treated malignancy less than 5 years prior to current resection (not including skin cancer); Resection done with non-curative intent or metastatic disease; other malignancies.