Tests needle bevel direction when puncturing fistulas for dialysis
Compares needle bevel direction in adults with kidney failure on hemodialysis.
Plain-language title generated from the registry record
Registry title: Impact of Bevel Orientation on Arteriovenous Fistula Puncture in Hemodialysis
Key facts
- Where
- Le Puy-en-Velay, Lyon, Moulins, and Poissy, FranceSee the 4 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 85 years old?
Source: NCT06708338, who can take part
Where in France
- Centre Hospitalier Emile RouxLe Puy-en-Velay, FranceTaking people
- Hôpital Saint Joseph Saint LucLyon, FranceNot yet recruiting
- Centre Hospitalier de Moulins-YzeureMoulins, FranceNot yet recruiting
- Ctre Hospitalier Intercommunal Poissy St Germain Site PoissyPoissy, FranceNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Centre Hospitalier Emile Roux
- Trial code
- NCT06708338
- Record updated
- 4 August 2026
- Original description
End-stage renal disease (ESRD) is a condition in which the filtration function of the kidneys has deteriorated, necessitating dialysis or transplantation. With an aging population, the number of patients undergoing dialysis for CKD is constantly increasing.Read full original descriptionShow less
Impact of Bevel Orientation on Arteriovenous Fistula Puncture in Hemodialysis: A Multicenter Randomized Comparative Study
End-stage renal disease (ESRD) is a condition in which the filtration function of the kidneys has deteriorated, necessitating dialysis or transplantation. With an aging population, the number of patients undergoing dialysis for CKD is constantly increasing.
There are different types of dialysis treatment: hemodialysis and peritoneal dialysis.
Hemodialysis involves exchanges between blood and a dialysate (a liquid used to purify blood) via a dialyzer (artificial filter), coordinated by a generator. This method requires a vascular approach, of which there are 3 types: the arteriovenous fistula (AVF), the arteriovenous graft and the central venous catheter.
The AVF remains the vascular access of choice for hemodialysis sessions, and its preservation is an essential objective for patients with CKD.
One of the major challenges for AVFs is to achieve a successful puncture, an act performed around 310 times a year per patient, for dialysis performed three times a week with double needles. This repeated procedure can cause damage to the AVF, leading to complications such as stenosis, thrombosis, aneurysm, superficial infection, hematoma, bleeding, parietal rupture or dissection.
However, there is no official recommendation on the most conservative puncture technique for AVF. In view of the number of patients concerned and the recurrence of puncture, it would seem essential to evaluate the impact of bevel orientation on the occurrence of complications during dialysis by means of a randomized prospective study.
Inclusion: male or female with Chronic Kidney Disease; patient requiring 4-hour hemodialysis sessions, 3 times per week, in a dialysis center; Native arteriovenous fistula (AVF) (without prosthesis), mature, with no prior puncture, located in the upper limb; First fistula for a hemodialysis patient; Expected duration of dialysis ≥ 1 year; Double-needle dialysis; Hemodialysis possible on AVF; Average AVF flow rate between 500 and 2,000 mL/min; Affiliated with a social security scheme; Free and informed consent.
Exclusion: Planned transplant within the next 12 months; Previous AVF creation, except for the fistula of interest; Patient with a history of cancer within the past 5 years or active cancer; Patient with psychiatric pathologies or cognitive disorders; Auto-dialysis at home; Puncture using the buttonhole technique; Patient requiring AVF puncture with a catheter; Patient under court protection or guardianship; Pregnant and breast-feeding women; Patient follow-up difficult or impossible for geographical or other reasons, at the investigator's discretion.