Freezing ovarian tissue to protect fertility in girls facing risky medical care
Tests freezing ovarian tissue in girls whose illness or treatment may threaten fertility.
Key facts
- Who runs it
- Phoenix Children's Hospital
- Where
- Phoenix, United StatesSee the site
- Trial code
- Registry title
- Ovarian Tissue Cryopreservation
- Status
- Recruiting
- People taking part
- 40 people, planned
- Started
- 30 Jul 2020
- Expected to end
- Jul 2031
- Type of study
- Interventional
- Treatments tested
- Ovarian tissue removal will be performed laparoscopically
- Record updated
- 23 January 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for girls and young women whose illness or planned treatment may harm their fertility. They can have ovarian tissue removed and frozen to protect future fertility.
- Age
- 1 Year to 25 Years
- Sex
- Female only
- Disease stage
- A newly diagnosed or relapsed cancer, or a health condition or cancer that needs removal of one or both ovaries. Health must be good enough for planned keyhole (laparoscopic) surgery, as judged by the anaesthesiologist.
- Earlier treatment
- Planned treatment must include at least one of: whole abdomen or pelvic radiation, total body irradiation, cyclophosphamide equivalent dose (CED) ≥7.5 g/m2, any regimen with procarbazine, or bone marrow transplant conditioning with alkylators. This does not apply to people who need ovary removal.
Main reasons for not taking part
- Being pregnant or currently breastfeeding
- Being able to have egg freezing and agreeing to it
- High risk of problems from the surgery or anaesthesia
- Unable to give consent because of a psychiatric condition or cognitive delay (parent or guardian consent for under 18)
The registry criteria, word for word
Show all 2 criteriaShow less
Who can take part
- Newly diagnosed or relapsed malignancy with proposed treatment regimen containing at least ONE (1) of the following:; whole abdomen or pelvic irradiation; total body irradiation; Proposed treatment regimen to include any of the following:; cyclophosphamide equivalent dose (CED, see Green et al 2014) ≥7.5 g/m2; any treatment regimen containing procarbazine; bone marrow transplant conditioning regimen containing alkylators; OR health condition or malignancy that requires removal of one or both ovaries. Health status adequate to undergo elective laparoscopic surgery (as per anesthesiologist assessment)
Who cannot take part
- Pregnancy or a patient who is currently breastfeeding; Patients who are eligible for and agree to oocyte preservation; Anyone deemed high risk for complications from the surgery and/or anesthesia; Anyone unable to provide consent due to psychiatric conditions or cognitive delay (in parent/guardian for patients <18 years, and patient >18 years)
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 1 and 25 years old?
Where in United States
- Phoenix ChildrensPhoenix, United StatesContact: Alexandra Walsh, MDTaking people
About the trial
What the trial wants to find out
Ovarian Tissue Freezing For Fertility Preservation In Girls Facing A Fertility Threatening Medical Diagnosis Or Treatment Regimen
The group in the trial
- girls facing possible infertilityOther group
Newly diagnosed female or relapsed malignancy who is 1-25 years of age with proposed treatment regimen containing at least ONE (1) of the following: whole abdomen or pelvic irradiation total body irradiation Proposed treatment regimen to include any of the following: cyclophosphamide equivalent dose (CED, see Green et al 2014) ≥7.5 g/m2 any treatment regimen containing procarbazine bone marrow transplant conditioning regimen containing alkylator OR health condition or malignancy that requires removal of one or both ovaries
Treatment: Ovarian tissue removal will be performed laparoscopically
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Ovarian Tissue Freezing For Fertility Preservation In Girls Facing A Fertility Threatening Medical Diagnosis Or Treatment Regimen
- Plain-language title
- Freezing ovarian tissue to protect fertility in girls facing risky medical careGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 15 November 2026.
- Fit questions
- Built from NCT06710769, who can take part
- Record updated
- 23 January 2026