Tests remote ischemic conditioning in adults with bleeding around the brain
Tests a device-based treatment against a sham device in adults with brain bleeding.
Key facts
- Who runs it
- Beijing Tiantan Hospital
- Where
- Beijing, ChinaSee the site
- Trial code
- Registry title
- Remote Ischemic Conditioning for Efficacy in Patients With Aneurysmal Subarachnoid Hemorrhage
- Status
- Not yet recruiting
- People taking part
- 500 people, planned
- Started
- 1 Jul 2025
- Planned end
- 1 Apr 2026
- Type of study
- Interventional, 2 groupsOne group gets a sham (pretend) treatment, for comparison.
- Treatments tested
- Sham RIC
- Remote Ischemic Conditioning treatment instrument
- Record updated
- 10 July 2025
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 18 to 80 with a bleed around the brain from a burst aneurysm, who had the aneurysm treated through the blood vessels and joined within 72 hours of onset.
- Age
- 18 to 80 years
- Sex
- Women and men can join.
- Disease stage
- Aneurysmal subarachnoid hemorrhage confirmed by imaging, Hunt-Hess grade 2-3 at admission, onset within 72 hours. The aneurysm must have been treated by endovascular interventional therapy.
- Earlier treatment
- The responsible aneurysm must already have been treated by endovascular interventional therapy.
Main reasons for not taking part
- Other brain bleeding or other types of subarachnoid hemorrhage
- Earlier neurological deficits (mRS score 1 or more) or psychiatric disorders that confuse the assessments
- Severe other illness with life expectancy under 90 days
- Refractory high blood pressure (systolic above 180 mmHg or diastolic above 110 mmHg)
- Contraindications to remote ischemic conditioning, such as severe soft tissue injury of the lower limbs
The registry criteria, word for word
Show all 13 criteriaShow less
Who can take part
- Patients with aneurysmal subarachnoid hemorrhage confirmed by imaging examination (diagnosed by computed tomography and confirmation of an intracranial aneurysm by CT angiography or digital subtraction angiography)
- The Hunt-Hess grade is 2-3 at admission
- Onset of aneurysmal subarachnoid hemorrhage ≤72 hours
- The responsible aneurysm has been treated by endovascular interventional therapy
- 18≤ age ≤80 years old
- Informed consent must be obtained from participants or legally authorized representatives
Who cannot take part
- Previous neurological deficits (mRS Score ≥1) or psychiatric disorders that can confound neurological or functional assessments
- Concurrent participation in another protocol investigating a different experimental therapy
- Patients with other intracerebral hemorrhage or other types of subarachnoid hemorrhage
- Refractory hypertension (Systolic blood pressure> 180 mmHg or diastolic blood pressure >110 mmHg)
- Any condition that the investigator believes may increase the patient's risk
- With severe comorbidities and a life expectancy of less than 90 days
- Contraindications of RIC: severe soft tissue injury of the lower limbs, etc
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Where in China
- Beijing Tiantan HospitalBeijing, ChinaContact: Aihua Liu, DoctorNo longer taking part
About the trial
What the trial wants to find out
Several recent large-scale clinical trials aimed at improving subarachnoid hemorrhage(SAH) outcomes have concluded with negative results, failing to enhance the prognosis for these patients. Consequently, there is an urgent demand for novel treatment strategies and approaches to address the challenges posed by SAH.
Read full original descriptionShow less
Remote ischemic conditioning(RIC) has gained considerable attention in the treatment of stroke, particularly ischemic stroke, with numerous studies demonstrating its potential to enhance neurological outcomes compared to conventional treatments alone.RIC for the treatment of SAH is an investigative strategy in its initial stages. The neuroprotective effects of RIC, particularly its potential to preserve cranial nerve function and ameliorate neurological deficits, confer significant value in the treatment of SAH patients.
The precise manner in which SAH patients may benefit from RIC treatment, and the mechanisms by which it improves neurological function, remain to be fully understood. Consequently, randomized controlled trials are necessary to validate the efficacy of RIC in this patient population and to delineate the optimal therapeutic protocols for its application.
Based on the above discussion, this study aims to explore the efficacy and safety of RIC in the treatment of SAH.
The 2 groups in the trial
- Sham groupSham treatment, for comparison
Guideline-based therapy+Sham RIC is given twice a day with 60mmHg pressure.
Treatment: Sham RIC
- RIC GroupTreatment being tested
Guideline-based therapy+RIC RIC is given twice a day with 200mmHg pressure.
Treatment: Remote Ischemic Conditioning treatment instrument
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Remote Ischemic Conditioning for Efficacy in Patients With Aneurysmal Subarachnoid Hemorrhage: a Multi-center, Randomized, Double-blind, Sham-controlled, Parallel-group Trial
- Plain-language title
- Tests remote ischemic conditioning in adults with bleeding around the brainGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT06711302, who can take part
- Record updated
- 10 July 2025