Blood pressure targets during surgery and thinking ability in cancer patients
Compares two blood pressure strategies during cancer surgery in people at high stroke risk.
Plain-language title generated from the registry record
Registry title: Different Intraoperative Blood Pressure Management on Postoperative Cognitive Function in Tumor Patients（PRECISION）
Key facts
- Where
- Hangzhou, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 85 years old?
Source: NCT06711432, who can take part
Where in China
- Zhejiang Cancer HospitalHangzhou, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Zhejiang Cancer Hospital
- Trial code
- NCT06711432
- Record updated
- 2 December 2024
- Original description
This is a randomized controlled study to explore whether perioperative blood pressure management with different strategies can reduce the incidence of delirium and postoperative cognitive impairment and serious perfusion related complications (persistent hypotension, new heart arrhythmia, cardiac insufficiency, new stroke, sudden death, etc.) within 30 days after stroke in cancer patients at high risk for stroke.Read full original descriptionShow less
Effects of Different Intraoperative Blood Pressure Management Strategies on Postoperative Cognitive Function and Adverse Outcomes in Tumor Patients With High Risk Factors for Stroke
This is a randomized controlled study to explore whether perioperative blood pressure management with different strategies can reduce the incidence of delirium and postoperative cognitive impairment and serious perfusion related complications (persistent hypotension, new heart arrhythmia, cardiac insufficiency, new stroke, sudden death, etc.) within 30 days after stroke in cancer patients at high risk for stroke.
Patients were randomly divided into: 1) strict blood pressure management group: norepinephrine or phenylephrine maintenance intraoperative MAP≥85 mmHg, and 2) conventional blood pressure management group: intraoperative routine blood pressure management (MAP≥65mmHg).
The study included 424 subjects and was randomized to provide 90% efficacy. Secondary markers were unscrupulous cerebrovascular events (persistent hypotension, arrhythmia, cardiac insufficiency, new stroke, sudden death) within 30 days after surgery.
Inclusion: Patients with high-risk stroke (combined with 3 risk factors or more according to the stroke risk screening table); Patients who plan to undergo surgery for abdominal tumors (gynecological, urinary, hepatobiliary, and gastrointestinal tumors) under general anesthesia are expected to have surgery duration >2 hours; The ASA is rated as Class II or III; Patients who underwent invasive arterial blood pressure monitoring before surgery signed informed consent.
Exclusion: Emergency surgery; Situations where strict blood pressure management is not appropriate, such as controlled hypotension during surgery; Patients with severe heart disease (severe valvular disease, sick sinus syndrome, high atrioventricular block without pacemaker implantation), grade III or above Liver function impairment (Child-Pugh class C); Need kidney replacement therapy; New stroke <3 months; Preoperative history of mental illness, epilepsy, Parkinson's disease, or myasthenia gravis; Speech, vision, or hearing impairment that prevents completion of a cognitive function assessment; Patients do not want to participate in the study.