Chemotherapy before surgery for locally advanced gallbladder cancer
Compares chemotherapy before surgery with surgery alone in gallbladder cancer.
Plain-language title generated from the registry record
Registry title: Neoadjuvant Chemotherapy for Locally Advanced Gall Bladder Cancer : a Randomized Control Trial (NEOGB)
Key facts
- Where
- Delhi, IndiaSee the site
- Phase
- Phase 3
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 70 years old?
Source: NCT06712420, who can take part
Where in India
- Rajiv Gandhi Cancer Institute and Research CentreDelhi, IndiaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Rajiv Gandhi Cancer Institute & Research Center, India
- Trial code
- NCT06712420
- Record updated
- 16 April 2025
- Original description
to study role of chemotherapy treatment for gall bladder cancer before surgery as compared to surgery directlyRead full original descriptionShow less
Neoadjuvant Chemotherapy Versus Upfront Surgery for Locally Advanced Resectable Gall Bladder Cancer : A Randomized Trial
to study role of chemotherapy treatment for gall bladder cancer before surgery as compared to surgery directly
Inclusion: ECOG 0-2; Locally advanced resectable GBC defined as Clinical T3/4 disease or Regional LN involvement on imaging studies; Post cholecystectomy GBC with residual disease on imaging, History of bile spillage during primary surgery , history of piece-meal removal of gall bladder during simple cholecystectomy, Regional LN involvement on imaging studies.
Exclusion: Locally advanced disease requiring major hepatectomy or whipple's pancreatoduodenectomy; Post cholecystectomy GBC without any evidence of spillage of residual disease on radiological imaging; Early GBC ( cT1/T2) without significant lymphadenopathy or liver infiltration on radiological imaging ; Obstructive jaundice due to involvement of biliary tree by tumour; Vascular involvement such as common hepatic artery, MPV right hepatic artery or right portal vein; Any distant metastasis or isolated port site metastasis; Involvement of non-regional LN (e.g . Celiac LN, SMA lymph node, inter-aortocaval or left para-ortic LN); Poor performance status ECOG 3 or more; Pregnancy; Inability or unwillingness to follow study protocol.